Paper Details

  1. Home
  2. Paper Details

Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors.

Author: ChenJuan, LiuJie, LiuYun, ShenYi-Wen, SunLu-Ning, WangYong-Qing, XieLi-Jun, ZhangHe-Jian, ZhangHong-Wen, ZhangXue-Hui, ZhouChen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review analyzed the effect of genetic polymorphisms on the pharmacodynamic and pharmacokinetic properties of proton pump inhibitors (PPIs).
Paper Details　
Original Abstract of the Article :
Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H<sup>+</sup>,K<sup>+</sup>-ATPase genotype. The aim of this...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.phrs.2019.104606

データ提供：米国国立医学図書館（NLM）

The Influence of Genetic Polymorphisms on Proton Pump Inhibitors

This review dives into the fascinating world of pharmacogenetics, exploring the impact of genetic variations on the pharmacokinetics and pharmacodynamics of proton pump inhibitors (PPIs). PPIs are widely used for treating acid-related disorders, but their efficacy and tolerability can vary significantly among individuals due to genetic differences. The review focuses on two key genes: CYP2C19, responsible for metabolizing PPIs, and gastric H+,K+-ATPase, the target enzyme of PPIs. The researchers highlight the influence of genetic polymorphisms in these genes on both the absorption and effectiveness of PPIs, with gastric H+,K+-ATPase polymorphisms having a greater impact on acid suppression.

Precision Medicine in Action: Tailoring PPI Treatment to Individual Genetics

This review emphasizes the importance of considering genetic variations when prescribing PPIs. The researchers highlight the need for personalized approaches that account for individual genetic profiles to optimize PPI treatment outcomes.

A Genetic Compass: Understanding the Influence of Polymorphisms on Drug Response

This review provides valuable insights into the complex interplay between genetic variations and drug response. By understanding the influence of polymorphisms in CYP2C19 and gastric H+,K+-ATPase, healthcare providers can make more informed decisions about PPI treatment, tailoring dosages and monitoring patient response accordingly.

Dr. Camel's Conclusion

This review underscores the crucial role of pharmacogenetics in optimizing drug therapy. The researchers' insights into the influence of genetic polymorphisms on PPI pharmacokinetics and pharmacodynamics highlight the need for personalized medicine approaches. By taking into account individual genetic profiles, healthcare providers can tailor PPI treatment, ensuring optimal efficacy and minimizing the risk of adverse effects. The future of medicine lies in harnessing the power of genetics to personalize treatments and improve patient outcomes.

Date :
  1. Date Completed 2021-01-04
  2. Date Revised 2021-01-04
Further Info :

Pubmed ID

31846760

DOI: Digital Object Identifier

10.1016/j.phrs.2019.104606

Related Literature

Article Analysis
・Effects of dexlansoprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.