Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib.

Author: AlivertisDimitrios, BrentasAlexios, NtemouNikoleta, PantaziDespoina, SkobridisKonstantinos, TselepisAlexandros D

Paper Details 
Original Abstract of the Article :
Platelets play important roles in cancer progression and metastasis, as well as in cancer-associated thrombosis (CAT). Tyrosine kinases are implicated in several intracellular signaling pathways involved in tumor biology, thus tyrosine kinase inhibitors (TKIs) represent an important class of antican...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913343/

データ提供:米国国立医学図書館(NLM)

Targeting Tyrosine Kinases: A New Frontier in Cancer Therapy

The fight against cancer is an ongoing journey through a vast and challenging desert. Researchers are constantly exploring new strategies to conquer this formidable foe. This study focuses on a promising approach: targeting tyrosine kinases, key players in intracellular signaling pathways that are often dysregulated in cancer.

Tyrosine Kinase Inhibitors: A Powerful Weapon in the Fight Against Cancer

The study examines the antiplatelet effects of synthetic analogues of the anticancer drugs imatinib and nilotinib. These drugs, known as tyrosine kinase inhibitors (TKIs), are specifically designed to block the activity of certain tyrosine kinases involved in cancer growth and spread. The researchers investigated the potential of these TKIs to inhibit platelet function, a crucial process in cancer progression and metastasis.

Hope for a New Era of Targeted Therapy

This research explores a novel strategy for combating cancer, combining the anti-cancer effects of TKIs with their potential to inhibit platelet activity. While further research is needed to fully understand the clinical implications of this approach, it opens a door to a new era of targeted therapy, where drugs are specifically designed to strike at the heart of cancer, while minimizing harm to healthy tissues.

Dr.Camel's Conclusion

The study sheds light on the potential of tyrosine kinase inhibitors as a multi-pronged approach to combat cancer. By targeting both cancer cells and platelet function, these drugs offer a promising avenue for more effective and less invasive treatment strategies. This is a significant step forward in the quest to find a cure for this devastating disease.

Date :
  1. Date Completed 2020-06-17
  2. Date Revised 2022-04-11
Further Info :

Pubmed ID

31849454

DOI: Digital Object Identifier

PMC6913343

Related Literature

SNS
PICO Info
in preparation
Languages

English

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