Evaluation of the potential effect of dacomitinib, an EGFR tyrosine kinase inhibitor, on ECG parameters in patients with advanced non-small cell lung cancer.

Author: GiriNagdeep, ParivarKourosh, QuinnSusan, TanWeiwei, WilnerKeith

Paper Details 
Original Abstract of the Article :
Purpose The study evaluated the potential effect of dacomitinib, a small molecule epidermal growth factor receptor (EGFR) inhibitor, on the electrocardiogram (ECG) parameters in adult patients with advanced non-small cell lung cancer enrolled in a multicenter, open-label, phase 2 study. Methods Pati...See full text at original site
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引用元:
https://doi.org/10.1007/s10637-019-00887-0

データ提供:米国国立医学図書館(NLM)

Dacomitinib and ECG Parameters: A Safety Evaluation

This study examines the potential effects of dacomitinib, an epidermal growth factor receptor (EGFR) inhibitor used to treat advanced non-small cell lung cancer, on electrocardiogram (ECG) parameters. The study aimed to evaluate the safety of dacomitinib with regard to its potential impact on the heart's electrical activity.

Dacomitinib's Safety Profile

The study found that dacomitinib, at therapeutic doses, had no clinically significant effect on ECG parameters. The drug did not prolong the QT interval, a measure of the time it takes for the ventricles of the heart to repolarize, nor did it significantly affect other ECG parameters, suggesting that dacomitinib is generally safe for use in patients with advanced non-small cell lung cancer.

Improving Cancer Treatment Safety

This research contributes to the growing body of knowledge regarding the safety of targeted cancer therapies. By carefully evaluating the potential impact of these medications on vital organs, researchers can ensure the development of safe and effective treatments for cancer patients.

Dr.Camel's Conclusion

Imagine the fight against cancer as a treacherous journey through the desert of illness. This study explores the safety of a new drug, dacomitinib, ensuring that it does not pose a threat to the patient's heart, their vital compass in this challenging terrain. This research emphasizes the importance of thorough safety assessments for new medications, protecting patients and allowing them to navigate the journey of cancer treatment with greater confidence and well-being.
Date :
  1. Date Completed 2021-06-01
  2. Date Revised 2021-06-01
Further Info :

Pubmed ID

31858327

DOI: Digital Object Identifier

10.1007/s10637-019-00887-0

Related Literature

SNS
PICO Info
in preparation
Languages

English

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