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Efficacy of PI3K inhibitors in advanced breast cancer.

Author: AndreF, ArnedosM, BachelotT, CortesJ, VerretB

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study reviews the research on PI3K inhibitors for breast cancer. It focuses on the role of the PI3K/Akt signaling pathway in breast cancer and highlights the potential of alpelisib, a specific PI3K inhibitor, in combination with fulvestrant.
Paper Details　
Original Abstract of the Article :
The phosphoinositide 3 (PI3)-kinase/Akt signaling pathway has always been a focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration and deregulated apoptosis. Its activation has been linked to endocrine resistance and worse prognosis in certain subgroups...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923787/

データ提供：米国国立医学図書館（NLM）

Targeting the PI3K Pathway: A New Frontier in Breast Cancer Treatment

Breast cancer is a complex disease, and the search for effective treatments continues. This research focuses on the phosphoinositide 3 (PI3)-kinase/Akt signaling pathway, which plays a key role in the growth and spread of cancer cells. The researchers discuss the potential of PI3K inhibitors, a class of drugs that block the activity of this pathway, in treating advanced breast cancer. They highlight the recent approval of alpelisib, a PI3K inhibitor, in combination with fulvestrant for the treatment of endocrine-resistant PIK3CA-mutant hormone receptor (HR)-positive breast tumors. The specificity of alpelisib against the p110α catalytic isoform provided additional efficacy and a better toxicity profile. The researchers also discuss the potential of future combinations of PI3K inhibitors with other treatments for breast cancer.

PI3K Inhibitors: A Targeted Approach to Breast Cancer Treatment

This research explores the potential of PI3K inhibitors as a targeted approach to breast cancer treatment. It's like using a laser to precisely target and eliminate specific cancer cells, minimizing damage to healthy tissues. The study highlights the recent approval of alpelisib, which is a significant step forward in the fight against breast cancer. The researchers suggest that alpelisib's specificity could lead to better outcomes and fewer side effects for patients.

Breast Cancer Treatment: A Journey of Innovation

The development of PI3K inhibitors is a testament to the ongoing innovation in breast cancer treatment. It's like building a new road through the desert, offering a faster and safer route to reach the destination. This research provides a glimpse into the future of breast cancer treatment, where targeted therapies play an increasingly important role.

Dr. Camel's Conclusion

The PI3K pathway is like a hidden oasis in the desert of breast cancer research. Targeting this pathway with inhibitors offers a promising new approach to treating advanced breast cancer. The development of alpelisib represents a significant step forward, but more research is needed to explore the full potential of this new treatment strategy.

Date :
  1. Date Completed 2020-06-25
  2. Date Revised 2023-10-27
Further Info :

Pubmed ID

31859349

DOI: Digital Object Identifier

PMC6923787

Related Literature

Article Analysis
・Side Effects of alpelisib
SNS
PICO Info
in preparation
Languages

English

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