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Perampanel tolerability in children and adolescents with focal epilepsy: Effects on behavior and executive functions.

Author: CarotenutoMarco, CoppolaGiangennaro, Di BonaventuraCarlo, EliaMaurizio, MatricardiSara, MazzaRoberta, OpertoFrancesca Felicia, PastorinoGrazia Maria Giovanna, VerrottiAlberto, ViggianoAndrea

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Overview

Perampanel (PER), a non-competitive AMPA glutamate receptor antagonist, has been approved for focal and generalized epilepsies. While PER is generally well-tolerated and effective in treating pediatric epilepsy syndromes, its effect on executive functions needs further investigation.
Paper Details　
Original Abstract of the Article :
Perampanel (PER) is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist recently approved for focal and generalized epilepsies as an add-on therapy. It is well tolerated and effective as treatment of various pediatric epilepsy syndromes; PER doe...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2019.106879

データ提供：米国国立医学図書館（NLM）

Perampanel for Pediatric Epilepsy: Exploring the Cognitive Landscape

The world of [pediatric epilepsy] is a complex and often challenging terrain, where seizures can disrupt a child's life. This study, like a careful explorer navigating a vast and unknown desert, delves into the effects of [perampanel (PER)] on the cognitive landscape of children and adolescents with [focal epilepsy]. Researchers investigated the impact of [PER] on [behavior and executive functions].

A Promise of Relief without Cognitive Burden

The findings suggest that [PER] may be well-tolerated and effective in treating [pediatric epilepsy syndromes]. Moreover, the study offers reassurance that [PER] does not appear to negatively affect the cognitive profiles of children and adolescents. This finding is particularly encouraging, as it suggests that [PER] can provide relief from seizures without compromising cognitive development.

Navigating the Challenges of Epilepsy

This study offers a glimmer of hope for patients with [pediatric epilepsy]. While further research is needed to fully understand the long-term cognitive effects of [PER], the findings suggest that it may be a viable and safe treatment option. Navigating the challenges of epilepsy requires a multifaceted approach that considers both the physical and cognitive well-being of patients.

Dr. Camel's Conclusion

This study highlights the potential of perampanel as a safe and effective treatment option for children and adolescents with focal epilepsy. It provides reassurance that this medication does not appear to negatively impact cognitive function, offering a promising avenue for managing seizures without compromising cognitive development.

Date :
  1. Date Completed 2020-11-16
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

31937512

DOI: Digital Object Identifier

10.1016/j.yebeh.2019.106879

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・Effects of perampanel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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