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Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism.
Author: AlvesNathan J, KlineJeffrey A, PikeJonathan W, PuskarichMichael A, ZagorskiJohn
Original Abstract of the Article :
BACKGROUND: We test if inhaled nitric oxide (NO) attenuates platelet functional and metabolic hyper-reactivity in subjects with submassive pulmonary embolism (PE). METHODS: Participants with PE were randomized to either 50 ppm NO + O2 or O2 only for 24 h with blood sampling at enrollment and after ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/31940502
データ提供:米国国立医学図書館(NLM)
Inhaled Nitric Oxide: A Potential Solution for Platelet Hyperactivity in Pulmonary Embolism?
Pulmonary embolism (PE), a blockage in the pulmonary arteries, can be a serious and life-threatening condition. This study investigates the potential of inhaled nitric oxide (NO) to reduce platelet hyperactivity in patients with submassive PE. The researchers compared the effects of inhaled NO with oxygen alone on platelet function and metabolism. The study's findings could provide valuable insights into the potential role of NO in managing PE. It’s like a camel who is trying to cross a desert with a sandstorm brewing – finding a way to calm the storm could make the journey safer.
NO's Promise: A Breath of Fresh Air for Platelet Hyperactivity
The study found that while inhaled NO successfully delivered to the lungs, it had no significant effect on platelet function or metabolism in patients with submassive PE. This suggests that NO may not be a viable treatment option for reducing platelet hyperactivity in this condition. It’s like a camel who tries to quench his thirst by drinking from a mirage – while it looks promising, it doesn’t provide any real relief.
Navigating the Treatment Landscape: Finding the Right Solution for Pulmonary Embolism
This study underscores the need for further research into effective therapies for platelet hyperactivity in PE. While NO shows promise in other settings, it may not be the ideal solution for this specific condition. It’s like a camel who has to choose between two paths through a desert – one path may be well-traveled but dangerous, while the other is unknown but potentially safer.
Dr.Camel's Conclusion
This study sheds light on the complexity of managing PE, a condition that requires a multifaceted approach. The findings suggest that while NO may offer benefits in other scenarios, it may not be the answer for platelet hyperactivity in submassive PE. It’s like a camel who is trying to find the best way to cross a desert – there is no single solution, and finding the right approach requires careful consideration and evaluation.
Date :
- Date Completed 2020-11-23
- Date Revised 2021-03-02
Further Info :
Related Literature
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