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Effects of silodosin and tadalafil on bladder dysfunction in spontaneously hypertensive rats: Possible role of bladder blood flow.
Author: FujiedaMikiya, HigashiYouichirou, KurabayashiAtsushi, NagaoYoshiki, SaitoMotoaki, ShimizuShogo, ShimizuTakahiro, TsudaMasayuki
Original Abstract of the Article :
OBJECTIVES: To investigate the effects of an alpha1-adrenoceptor antagonist, silodosin, or a phosphodiesterase type 5 inhibitor, tadalafil, on bladder overactivity in spontaneously hypertensive rats. METHODS: Twelve-week-old male spontaneously hypertensive rats were perorally administered silodosin...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/iju.14171
データ提供:米国国立医学図書館(NLM)
High Blood Pressure and Bladder Dysfunction: A Connection Worth Exploring
This research explores the effects of high blood pressure on bladder function, specifically examining the potential benefits of silodosin and tadalafil in managing bladder overactivity in spontaneously hypertensive rats. The study found that both silodosin and tadalafil improved urodynamic parameters and bladder blood flow in these rats, suggesting a potential therapeutic role for these medications in managing hypertension-related bladder dysfunction.
High Blood Pressure: More Than Just Heart Issues
The study reveals a potential link between high blood pressure and bladder dysfunction, highlighting the importance of considering the impact of hypertension on other organs and systems. The findings suggest that medications commonly used for hypertension may also offer benefits in managing bladder overactivity associated with high blood pressure.
A New Avenue for Managing Bladder Dysfunction
This research suggests that silodosin and tadalafil, medications typically used for prostate problems and erectile dysfunction, respectively, may also have a therapeutic role in managing bladder dysfunction associated with high blood pressure. These findings open up new avenues for exploring the potential of existing medications in managing bladder dysfunction, potentially leading to more effective and personalized treatment strategies for patients.
Dr. Camel's Conclusion
This research reminds us that the desert of medical knowledge is vast and interconnected. Just as a desert ecosystem is composed of intricate relationships between plants, animals, and the environment, our bodies are interconnected systems. This study highlights the potential link between high blood pressure and bladder dysfunction, suggesting that medications commonly used for one condition may offer benefits for another. It's a reminder that the desert is full of surprises, and that by exploring these connections, we can discover new and innovative approaches to managing complex health issues.
Date :
- Date Completed 2021-04-27
- Date Revised 2021-04-27
Further Info :
Related Literature
English
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