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Recently Approved and Upcoming Treatments for Narcolepsy.

Author: ThorpyMichael J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Narcolepsy is a chronic, disabling neurologic disorder characterized by excessive daytime sleepiness (EDS) and cataplexy. This review summarizes the mechanisms of action, pharmacokinetics, efficacy, and safety/tolerability of recently approved and emerging treatments for narcolepsy.
Paper Details　
Original Abstract of the Article :
Narcolepsy is a chronic, disabling neurologic disorder characterised by excessive daytime sleepiness (EDS) and, in up to 60% of patients, cataplexy. Treatments for narcolepsy are aimed at improving wakefulness (e.g. modafinil, armodafinil, stimulants), reducing cataplexy attacks (e.g. sodium oxybate...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982634/

データ提供：米国国立医学図書館（NLM）

Awakening from the Desert: New Treatments for Narcolepsy

Narcolepsy, a chronic neurological disorder, can be like a desert mirage, causing excessive daytime sleepiness and other disruptive symptoms. This review summarizes the recently approved and emerging treatments for narcolepsy, offering potential oases of relief for those struggling with this challenging condition.

Finding a Path Through the Desert: New Treatments for Narcolepsy

The review highlights the various medications currently available for narcolepsy, including those aimed at improving wakefulness, reducing cataplexy attacks, and addressing other symptoms like sleep paralysis and hallucinations. This is like a camel caravan navigating the desert, using various tools and strategies to reach its destination safely.

A New Oasis of Hope: Emerging Treatments for Narcolepsy

The review also discusses several new agents currently being developed and tested as potential treatments for narcolepsy. These include novel oxybate formulations, a selective norepinephrine reuptake inhibitor, and a combination product of modafinil and an astroglial connexin inhibitor. These emerging treatments offer a potential oasis of hope for those seeking more effective and tolerable options.

Dr. Camel's Conclusion

This review offers a comprehensive overview of the current and emerging treatments for narcolepsy. It is like a desert guidebook, providing a roadmap for navigating the complex landscape of this challenging condition. By understanding the mechanisms of action, efficacy, and safety of these treatments, we can better manage narcolepsy and help those affected reach a more fulfilling and restful existence.
Date :
  1. Date Completed 2021-06-09
  2. Date Revised 2021-06-09
Further Info :

Pubmed ID

31953791

DOI: Digital Object Identifier

PMC6982634

Related Literature

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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