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[Torsade de pointes following repeated massive loperamide ingestions].
Author: CarlssonHåkan, HöjerJonas, MyllymäkiLinda, WesterberghJenny
Original Abstract of the Article :
The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses. However, at very high doses bioavailability increases, due to saturation of P-glycoprotein and first-pass metabolism, leading both to opioid effects on the central nervous system and possi...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/32016923
データ提供:米国国立医学図書館(NLM)
Loperamide: A Double-Edged Sword in the Desert of Diarrheal Relief
This study explores the potential dangers associated with high-dose loperamide, a commonly used anti-diarrheal medication. The authors present a case study of a patient who experienced life-threatening cardiovascular symptoms following prolonged daily intake of massive loperamide doses. The study highlights the potential for loperamide to cause Torsade de Pointes, a serious heart rhythm abnormality, at high doses. This research underscores the importance of adhering to recommended dosages and recognizing the potential risks associated with high-dose loperamide use. The study serves as a cautionary tale, emphasizing the need for careful monitoring and individualized treatment strategies.
Navigating the Desert of Medication: A Journey with Caution
The research underscores the importance of approaching medication with caution and recognizing the potential for unintended consequences. Just as a desert traveler must be wary of mirages and hidden dangers, so too must we be mindful of the potential side effects of medications. This research highlights the importance of adhering to recommended dosages and consulting with healthcare professionals to ensure safe and effective treatment. By understanding the potential risks associated with medications, we can make informed decisions that prioritize our health and wellbeing.
Heart Health: A Precious Oasis in the Desert
The study's findings remind us of the importance of safeguarding our heart health. Just as an oasis provides a lifeline in the desert, so too does a healthy heart sustain our physical well-being. This research encourages us to be mindful of our heart health, taking steps to mitigate risk factors and seeking prompt medical attention when necessary. By prioritizing heart health, we can enjoy a fulfilling and vibrant life, just as a camel thrives in the harsh desert environment.
Dr.Camel's Conclusion
This study serves as a powerful reminder that even seemingly safe medications can pose risks at high doses. As we navigate the world of healthcare, we must approach medication with a discerning eye, prioritizing our health and wellbeing.
Date :
- Date Completed 2020-07-07
- Date Revised 2020-07-07
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