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Protective Effects of Evening Primrose Oil against Cyclophosphamide-Induced Biochemical, Histopathological, and Genotoxic Alterations in Mice.
Author: Abdel-DaimMohamed M, AbushoukAbdelrahman I, KhodeerDina M, MehannaEman T
Original Abstract of the Article :
Cyclophosphamide (CP) is a well-known antineoplastic agent; however, its clinical use can be associated with various organ toxicities. Evening primrose oil (EPO) contains several phytoconstituents with potent anti-oxidant and anti-inflammatory activities. This experimental study was performed to inv...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168665/
データ提供:米国国立医学図書館(NLM)
Evening Primrose Oil: A Potential Protector Against Chemotherapy Toxicity
Chemotherapy is a powerful cancer treatment, but it can also cause significant side effects, including damage to organs like the liver and pancreas. This study investigates the protective effects of evening primrose oil (EPO) against cyclophosphamide (CP)-induced toxicity in mice. EPO contains various phytoconstituents known for their antioxidant and anti-inflammatory properties.
EPO: Protecting Against Chemotherapy-Induced Toxicity
The study found that EPO significantly mitigated CP-induced damage to the liver and pancreas in mice. EPO pretreatment reduced the levels of liver enzymes, pancreatic amylase, and malondialdehyde (a marker of oxidative stress), and increased serum insulin levels. EPO also improved tissue architecture, reducing inflammation and DNA fragmentation in both the liver and pancreas.
A Promising Approach to Mitigating Side Effects
This research suggests that EPO may have potential as a protective agent against chemotherapy-induced toxicity. Further investigation is needed to explore the potential clinical benefits of EPO in humans undergoing chemotherapy.
Dr. Camel's Conclusion
Think of a camel's ability to store water in its hump, a natural defense against the harsh desert environment. EPO, like a camel's hump, provides a natural defense against the potential toxicity of chemotherapy. This study suggests that EPO could be a valuable tool in mitigating the side effects of cancer treatment, potentially improving the quality of life for patients undergoing chemotherapy.
Date :
- Date Completed n.d.
- Date Revised 2020-09-28
Further Info :
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