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Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells.

Author: BuderathPaul, ErdmannKati, GohlkeBjörn Oliver, HilgerRalf Axel, KuhlmannJan Dominik, MelnikovaMargarita, MendusDiana, MercerKim, NeubauerHans, NiederacherDieter, OliverTrudy G, ThomaleJürgen, WauerUlrike Sophie, WimbergerPauline

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study identified diphenhydramine (DIPH) as a pharmacological agent that could enhance cisplatin (CP) efficacy while reducing its side effects. DIPH decreased DNA platination in normal tissues and ameliorated CP-induced toxicity in a mouse model. It also sensitized multiple cancer cell types to CP by increasing intracellular uptake, DNA platination, and/or apoptosis.
Paper Details　
Original Abstract of the Article :
Platinum-based compounds remain a well-established chemotherapy for cancer treatment despite their adverse effects which substantially restrict the therapeutic windows of the drugs. Both the cell type-specific toxicity and the clinical responsiveness of tumors have been associated with mechanisms th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138396/

データ提供：米国国立医学図書館（NLM）

Diphenhydramine: A New Tool in the Desert of Cancer Treatment

Cancer, a formidable adversary, is a desert of complexity and uncertainty. Platinum-based compounds, a mainstay of chemotherapy, can effectively combat cancer cells but often come with significant side effects, limiting their therapeutic window. This study delves into the potential of diphenhydramine, a commonly used antihistamine, to improve the therapeutic window of platinum drugs, offering a new strategy for navigating the desert of cancer treatment.

Diphenhydramine: A Double-Edged Sword Against Cancer

The study reveals that diphenhydramine, in its bimethylated form, simultaneously sensitizes tumor cells to cisplatin, a common platinum drug, while protecting normal tissues from accumulating damage. This dual action allows diphenhydramine to enhance the efficacy of platinum drugs while minimizing their side effects. The study also reveals that diphenhydramine inhibits the activity of efflux pumps, mechanisms that can export drugs from cells, potentially contributing to its sensitization effect.

Navigating the Desert of Cancer Treatment: Seeking Precise and Effective Therapies

This study highlights the potential of repurposing existing drugs, like diphenhydramine, to improve the efficacy of cancer treatments. By understanding the complex interplay between cancer cells, normal cells, and drugs, we can develop more precise and effective therapies, offering hope for those battling cancer.

Dr. Camel's Conclusion

This study showcases the potential of diphenhydramine as a powerful ally in the fight against cancer. By enhancing the efficacy of platinum drugs while mitigating their side effects, diphenhydramine offers a new and promising approach to cancer treatment. As we continue to explore the vast and complex desert of cancer, we can hope for more targeted and effective therapies to emerge, bringing us closer to a cure.

Date :
  1. Date Completed 2021-02-01
  2. Date Revised 2021-02-01
Further Info :

Pubmed ID

32037720

DOI: Digital Object Identifier

PMC7138396

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・Side Effects of diphenhydramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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