Paper Details 
Original Abstract of the Article :
Olanzapine has been used for the treatment of schizophrenia and other mental disorders. However, it is associated with serious weight gain and other metabolic side-effects. The antagonistic affinity of olanzapine to muscarinic M3 receptors has been evidenced as one of the main contributors for its w...See full text at original site
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引用元:
https://doi.org/10.1016/j.pbb.2020.172878

データ提供:米国国立医学図書館(NLM)

Addressing Olanzapine-Induced Metabolic Side Effects

The field of [pharmacology] is constantly seeking ways to mitigate the adverse effects of medications. This research investigates the potential of [cevimeline], a [muscarinic M3 receptor agonist], in preventing the metabolic side effects associated with [olanzapine] medication. The study uses a [female rat model] to explore the dosage-dependent effects of [cevimeline] on [olanzapine]-induced weight gain and other metabolic disturbances. The findings provide valuable insights into the potential therapeutic applications of [cevimeline] in managing the metabolic side effects of [olanzapine].

Cevimeline Shows Promise in Ameliorating Olanzapine-Induced Metabolic Side Effects

This research demonstrates the potential of [cevimeline] to mitigate the metabolic side effects associated with [olanzapine] medication. The study found that co-treatment with [cevimeline] partially reversed [olanzapine]-induced weight gain, food intake, and other metabolic disturbances in a dosage-dependent manner. This suggests that [cevimeline] may offer a promising therapeutic strategy for managing the metabolic side effects of [olanzapine] medication.

Understanding Drug Interactions and Metabolic Health

This research highlights the importance of understanding drug interactions and their impact on metabolic health. The study demonstrates the potential of [cevimeline] to mitigate the metabolic side effects of [olanzapine] medication. This knowledge can help healthcare providers make informed decisions about medication use, particularly in individuals at risk for [metabolic disturbances].

Dr.Camel's Conclusion

This research investigates the potential of [cevimeline] in preventing the metabolic side effects associated with [olanzapine] medication. The study found that co-treatment with [cevimeline] partially reversed [olanzapine]-induced weight gain, food intake, and other metabolic disturbances in a dosage-dependent manner. This suggests that [cevimeline] may offer a promising therapeutic strategy for managing the metabolic side effects of [olanzapine] medication.

Date :
  1. Date Completed 2021-01-07
  2. Date Revised 2021-01-07
Further Info :

Pubmed ID

32112786

DOI: Digital Object Identifier

10.1016/j.pbb.2020.172878

SNS
PICO Info
in preparation
Languages

English

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