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Approved and emerging PI3K inhibitors for the treatment of chronic lymphocytic leukemia and non-Hodgkin lymphoma.
Author: KienleDirk L, StilgenbauerStephan
Original Abstract of the Article :
PI3K inhibition with idelalisib (at that time CAL-101) was at the forefront of the development of molecularly targeted therapies in Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) and follicular lymphoma. However, after initial approval, subsequent trials identified specific immu...See full text at original site
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引用元:
https://doi.org/10.1080/14656566.2020.1737010
データ提供:米国国立医学図書館(NLM)
PI3K Inhibitors: A New Era of Targeted Therapies for Blood Cancers
Chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma are serious blood cancers that require effective treatment. PI3K inhibitors, a class of drugs that target a specific signaling pathway involved in cancer cell growth, have emerged as a promising new approach to treating these diseases. This review examines the development and use of PI3K inhibitors for CLL and non-Hodgkin lymphoma. Researchers explore the potential benefits of PI3K inhibition, as well as the challenges and limitations associated with these therapies.
PI3K Inhibitors: A Shift in Treatment Paradigm
The development of PI3K inhibitors represents a shift in the treatment paradigm for CLL and non-Hodgkin lymphoma. These targeted therapies offer the potential for improved efficacy and reduced side effects compared to traditional chemotherapy. However, challenges remain, such as the development of drug resistance and the identification of specific toxicities. Researchers continue to refine these therapies to optimize their effectiveness and minimize their adverse effects. This research is like discovering a new oasis in a desert, a potential source of healing and renewal, but with the need for careful exploration and understanding to ensure its safety and effectiveness.
PI3K Inhibitors: A Promise for Personalized Medicine
This review highlights the potential of PI3K inhibitors as a promising avenue for personalized medicine. By targeting specific signaling pathways involved in cancer cell growth, these therapies offer the potential for more effective and targeted treatment. However, as with any new therapy, careful monitoring and research are essential to ensure its safe and effective application.
Dr.Camel's Conclusion
This review offers a glimpse into the exciting field of PI3K inhibitors. It's like finding a hidden treasure in a desert, a new tool that could revolutionize the treatment of blood cancers. While these therapies hold immense promise, continued research is vital to ensure their safety, effectiveness, and to address any emerging challenges.
Date :
- Date Completed 2020-07-20
- Date Revised 2022-04-14
Further Info :
Related Literature
English
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