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Original Abstract of the Article :
Isotretinoin is chemically named as: (2Z, 4E, 6E, 8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid. It is an orally active retinoic acid derivative for the treatment of severe refractory nodulocystic acne. It acts primarily by reducing sebaceous gland size and sebum pr...See full text at original site
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引用元:
https://doi.org/10.1016/bs.podrm.2019.10.005
データ提供:米国国立医学図書館(NLM)
Isotretinoin: A Powerful Weapon Against Acne, But Not Without Its Risks
The field of dermatology is constantly seeking innovative solutions for the treatment of stubborn skin conditions. This research dives deep into the world of isotretinoin, a potent oral retinoid known for its effectiveness in managing severe acne. The study employs a comprehensive approach, delving into the chemical makeup, preparation methods, and pharmacological actions of isotretinoin. The authors meticulously unravel the secrets behind this medication, shedding light on its mechanism of action and its impact on sebaceous gland function. This research is like a treasure map guiding us through the intricate workings of isotretinoin, revealing its strengths and potential pitfalls. The authors highlight the remarkable efficacy of isotretinoin in achieving significant clearance of inflammatory lesions in acne patients. However, they also emphasize the importance of careful consideration due to the potential side effects, particularly concerning its contraindication for women of childbearing age. This research serves as a valuable guide for dermatologists, offering insights into the appropriate use and management of isotretinoin.
Isotretinoin: A Miracle Cure or a Double-Edged Sword?
This research reveals the impressive efficacy of isotretinoin in achieving significant improvement in acne. The study shows that using isotretinoin for 1-2mg/kg/day for 3-4 months results in 60%-95% clearance of inflammatory lesions in patients with acne. This is a significant finding, highlighting the potential of isotretinoin to dramatically improve the lives of those struggling with severe acne. However, it is important to recognize the double-edged nature of this medication. The research underscores the crucial importance of careful monitoring and responsible use of isotretinoin, given its potential side effects.
Navigating The Desert of Side Effects
The research highlights the potential side effects of isotretinoin, including those affecting the mucocutaneous system and elevated serum triglyceride levels. This emphasizes the importance of a thorough assessment of individual patient risks and benefits before prescribing isotretinoin. It's like navigating a vast desert; while the oasis of clearer skin may be tempting, one must be prepared for the potential challenges along the way. The strict contraindication for women of childbearing age is a crucial piece of information. It is imperative for healthcare professionals to educate patients about the potential risks and implications of using isotretinoin.
Dr.Camel's Conclusion
Isotretinoin is a powerful tool in the arsenal of dermatologists, offering significant hope for patients with severe acne. However, it is not a cure-all. Like a well-trained camel navigating a challenging desert, healthcare providers must carefully weigh the potential benefits and risks of isotretinoin, ensuring its use is appropriate and safe for individual patients.
Date :
- Date Completed 2020-07-13
- Date Revised 2020-07-13
Further Info :
Related Literature
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