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Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole.
Author: DurgunMeltem E, GüngörSevgi, KahramanEmine, ÖzsoyYıldız
Original Abstract of the Article :
Topical therapy is preferred for the management of ocular fungal infections due to its superiorities which include overcoming potential systemic side effects risk of drugs, and targeting of drugs to the site of disease. However, the optimization of effective ocular formulations has always been a maj...See full text at original site
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.2174/1381612826666200313172207
データ提供:米国国立医学図書館(NLM)
Optimizing Ocular Drug Delivery: A Desert Oasis of Micellar Formulations
Ocular fungal infections, like a persistent sandstorm in the eye, can be challenging to treat. This research investigates the potential of micellar formulations to improve the delivery of posaconazole, an antifungal drug, to the eye. The study explores the development and characterization of micellar formulations that can enhance the solubility and delivery of posaconazole, ultimately leading to more effective treatment for ocular fungal infections.
Navigating the Desert of Ocular Barriers: Micellar Formulations
The eye's intricate barriers, like a series of desert dunes, can make it difficult for drugs to reach the desired site of action. Micellar formulations, like a camel caravan navigating a treacherous landscape, can overcome these barriers, delivering the drug effectively to the eye. The study found that micellar carriers can improve the solubility of posaconazole, a highly lipophilic drug, enhancing its ability to penetrate ocular barriers and reach the infected tissues.
A Desert Oasis of Clarity: Improved Drug Delivery
This research offers a promising approach to improving the treatment of ocular fungal infections. The development of micellar formulations, like a hidden oasis in the desert, can enhance drug delivery and potentially lead to more effective and targeted therapies for eye infections. By continuing to explore innovative drug delivery systems, we can create a brighter future for patients battling ocular fungal infections.
Dr. Camel's Conclusion
This research highlights the potential of micellar formulations as a novel approach to improving ocular drug delivery. By overcoming the challenges posed by ocular barriers, these formulations can enhance the efficacy of antifungal medications and provide patients with a more effective means of combatting eye infections.
Date :
- Date Completed 2020-11-30
- Date Revised 2020-11-30
Further Info :
Related Literature
English
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