Paper Details

  1. Home
  2. Paper Details

New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals.

Author: AlmeidaCoral-Ann, ChooLinda, ChopraAbha, DeshpandePooja, DunnDavid, GaudieriSilvana, JamesIan, LearyShay, LiYueran, MallalSimon A, MontanerJulio, NolanDavid, PavlosRebecca, PhillipsElizabeth J, RachlisAnita, RauchAndri, RedwoodAlec J, ShaeferMark, StrautinsKaija, ThorbornDaren

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated immune and non-immune related genes in abacavir hypersensitivity syndrome (ABC HSS) and ABC tolerant patients to determine other factors required for the development of ABC HSS. The results showed that patients with ABC HSS were significantly less likely to carry only ERAP1 hypoactive trimming allotypes compared to those who tolerate ABC. These findings suggest that ERAP1 allotypes that favor efficient peptide trimming are more common in ABC HSS patients. Non-specific immune activation via soluble cluster of differentiation antigen 14 (sCD14) may also influence susceptibility to ABC HSS.
Paper Details　
Original Abstract of the Article :
Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-im...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/32173028

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Abacavir Tolerance: A Genetic Perspective

The world of [pharmacogenetics] explores the intricate interplay between genetics and drug response. This study focuses on abacavir hypersensitivity syndrome (ABC HSS), a serious side effect associated with the antiretroviral drug abacavir. The researchers investigated genetic factors that contribute to the development of ABC HSS, aiming to identify predictors of abacavir tolerance. They found that the presence of specific ERAP1 allotypes, which are variations in a gene involved in immune response, was associated with increased susceptibility to ABC HSS. This study provides valuable insights into the genetic basis of abacavir tolerance, potentially paving the way for personalized medicine approaches to managing HIV infection.

Unlocking the Secrets of Abacavir Tolerance: A Genetic Blueprint

This study offers a compelling glimpse into the genetic underpinnings of abacavir tolerance. The researchers' discovery of the association between specific ERAP1 allotypes and ABC HSS provides a potential genetic blueprint for predicting individual susceptibility to this adverse reaction. This knowledge could help healthcare providers make informed decisions about abacavir use, potentially avoiding the risks of ABC HSS.

Navigating the Terrain of Personalized Medicine

Imagine navigating a vast desert, where different paths lead to diverse outcomes. The field of personalized medicine, much like choosing the right path through the desert, aims to tailor treatments to individual genetic profiles. This study, by identifying genetic predictors of abacavir tolerance, highlights the potential of personalized approaches to managing HIV infection, ensuring that patients receive the most appropriate and effective care.

Dr. Camel's Conclusion

As a researcher who has journeyed through the vast desert of pharmacogenetics, I'm always fascinated by the intricate dance between our genes and our response to medications. This study on the genetic predictors of abacavir tolerance offers a compelling glimpse into the potential of personalized medicine. The researchers' discovery of the link between specific ERAP1 allotypes and ABC HSS is a significant step forward in understanding the genetic basis of drug response. This research holds promise for optimizing treatment strategies and ensuring safer and more effective management of HIV infection.

Date :
  1. Date Completed 2021-02-19
  2. Date Revised 2021-02-19
Further Info :

Pubmed ID

32173028

DOI: Digital Object Identifier

NIHMS1590559

Related Literature

Article Analysis
・Side Effects of abacavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.