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Antitumorigenic action of nelfinavir: Effects on multiple myeloma and hematologic malignancies (Review).

Author: AllegraA, AllegraA G, InnaoV, MusolinoC, PuglieseM, PulvirentiN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nelfinavir (NFV) is a protease inhibitor (PI) that inhibits HIV protease, stopping the cleavage of viral polyproteins into functional proteins and thus hindering virus replication. NFV has demonstrated anticancer activity in tumor patients, both with and without HIV, and its mechanisms of action include necrosis, apoptosis, and autophagy. NFV has shown promise in treating hematologic malignancies like acute myeloid leukemia, chronic lymphoid leukemia, diffuse large B cell lymphoma, and multiple myeloma. More research is needed to determine the role of NFV in cancer treatment and facilitate its use in clinical practice.
Paper Details　
Original Abstract of the Article :
Protease inhibitors (PIs) inhibit HIV‑1 and HIV‑2 proteases, impeding virus replication and liberation of viral elements from infected cells. In human immunodeficiency virus (HIV) subjects receiving PI‑based treatment, an impressive decrease in the amount of HIV‑associated cancers, unconnected to vi...See full text at original site
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引用元：
https://doi.org/10.3892/or.2020.7562

データ提供：米国国立医学図書館（NLM）

Nelfinavir: A Potential Weapon in the Fight Against Cancer

Protease inhibitors (PIs) have been a cornerstone of HIV treatment, but recent research suggests that they may also hold promise for cancer therapy. This review explores the antitumorigenic potential of nelfinavir (NFV), a nonpeptidic PI, focusing on its effects on multiple myeloma and other hematologic malignancies. The authors examine preclinical research and clinical trials, highlighting NFV's ability to induce cell death in tumor cells through various mechanisms, including necrosis, apoptosis, and autophagy. The review suggests that NFV, while not commonly used for antiretroviral treatment, could potentially play a significant role in the treatment of hematologic malignancies.

Nelfinavir: A New Frontier in Cancer Treatment

This review explores the intriguing potential of nelfinavir as a novel therapeutic agent for cancer treatment. It's like discovering a hidden oasis in the desert of cancer research, offering a new path to combatting this complex disease. The findings suggest that NFV, a drug previously known for its antiretroviral properties, could be a powerful tool in the fight against cancer.

Exploring New Avenues: Nelfinavir for Hematologic Malignancies

Cancer treatment is a challenging field, often requiring a multi-faceted approach. This review explores the potential of nelfinavir as a new weapon in the fight against hematologic malignancies. It's like finding a new arrow in your quiver, offering a different perspective and potentially a more effective way to combat these diseases.

Dr. Camel's Conclusion

This review provides a fascinating glimpse into the potential of nelfinavir as a promising therapeutic agent for cancer treatment. It's like discovering a new, hidden oasis in the vast desert of cancer research, offering hope for a future where this debilitating disease can be effectively treated. While further research is needed to fully understand the potential of NFV, the findings presented in this review are encouraging and warrant further investigation.

Date :
  1. Date Completed 2020-10-15
  2. Date Revised 2021-10-22
Further Info :

Pubmed ID

32236596

DOI: Digital Object Identifier

10.3892/or.2020.7562

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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