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Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites.

Author: ChouTz-Chong, HuangWen-Hsin, ShuiHao-Ai, SuWen-Lin, WengYu-Ya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of dextromethorphan (DM) and its metabolites on platelet aggregation *in vitro* and inflammatory pain in rats. DM and its metabolites inhibited platelet aggregation and reduced inflammatory pain.
Paper Details　
Original Abstract of the Article :
Label="Objective">In the present study, we investigated the effects of dextromethorphan (DM) and its metabolites, including dextrorphan (LK2), 3-methoxymorphinan (LK3), and 3-hydroxymorphinan (LK4), on platelet aggregation <i>in vitro</i> and the inflammatory pain caused by carrageenan in rats, and ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137376/

データ提供：米国国立医学図書館（NLM）

Dextromethorphan: A Camel's Oasis for Pain Relief

Pain is a universal experience, and finding effective and safe analgesics is a constant quest. This study delves into the pain-relieving properties of dextromethorphan, a common over-the-counter cough suppressant, and its metabolites. The researchers investigated the effects of dextromethorphan and its metabolites, including dextrorphan, 3-methoxymorphinan, and 3-hydroxymorphinan, on platelet aggregation and inflammatory pain in rats.

The study found that dextromethorphan and its metabolites exhibited antiplatelet effects in vitro and reduced inflammatory pain in rats. This suggests that dextromethorphan may have potential as an analgesic agent, particularly for inflammatory pain.

A Camel's Compass for Pain Management

The study's findings suggest that dextromethorphan and its metabolites could offer alternative approaches to pain management. However, it is important to note that this research was conducted in rats, and further research is needed to confirm its efficacy and safety in humans.

Dr. Camel's Conclusion

This study delves into the therapeutic potential of dextromethorphan, a common cough suppressant, for pain relief. The findings suggest that dextromethorphan and its metabolites could offer novel approaches to managing inflammatory pain, but more research is needed to explore their safety and effectiveness in humans.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

32269947

DOI: Digital Object Identifier

PMC7137376

Related Literature

Article Analysis
・Effects of dextromethorphan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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