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Electrospun Nimodipine-loaded fibers for nerve regeneration: Development and in vitro performance.

Author: GreinerAndreas, GöttelBenedikt, KnolleWolfgang, LeiszSandra, MäderKarsten, SchellerChristian, StraussChristian, SyrowatkaFrank, ZechJohanna

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Nimodipine, a calcium antagonist, has neuroprotective properties but its systemic use can cause side effects. This study developed electrospun fibers containing nimodipine that release the drug slowly over several days. These fibers showed no toxicity and protected cells from stress, suggesting potential for local controlled release of nimodipine in the brain.
Paper Details　
Original Abstract of the Article :
Nimodipine is a 1,4-Dihydropyridine type calcium antagonist routinely used to control blood pressure and reduce the risk of secondary ischemia after aneurismal subarachnoid hemorrhage. Additionally, Nimodipine has unique neuroprotective properties. With respect to brain related applications, the ful...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2020.03.021

データ提供：米国国立医学図書館（NLM）

Electrospun Nimodipine-Loaded Fibers: A Novel Approach to Nerve Regeneration

This research explores the potential of electrospun fibers loaded with nimodipine, a calcium channel blocker, as a drug delivery system for nerve regeneration. The study investigates the development and in vitro performance of these fibers, which are designed to deliver nimodipine directly to the site of injury, providing localized therapeutic effects. The researchers aimed to overcome the limitations of systemic nimodipine administration, which can lead to undesirable side effects.

Delivering Nimodipine Locally: A Targeted Approach to Nerve Repair

The study demonstrates the successful development of biodegradable poly(lactic-co-glycolic acid) (PLGA) fibers containing nimodipine. They observed that the drug was incorporated into the polymer matrix in an amorphous state, ensuring a sustained release over several days. Furthermore, they found that these fibers did not exhibit cytotoxicity and, importantly, significantly reduced cell death in various in vitro models of neuronal stress.

Hope for Nerve Regeneration: Exploring New Therapeutic Strategies

This research holds promise for the treatment of nerve injuries. The development of electrospun nimodipine-loaded fibers could provide a targeted and effective way to deliver this neuroprotective drug directly to the site of injury, promoting nerve regeneration and improving patient outcomes.

Dr.Camel's Conclusion

This research is like discovering a new type of desert plant that has remarkable healing properties. Electrospun nimodipine-loaded fibers are a novel and promising approach to nerve repair, offering a more targeted and localized treatment option. The future of nerve regeneration may hold even more exciting possibilities, just as the desert holds hidden treasures waiting to be discovered.
Date :
  1. Date Completed 2021-02-09
  2. Date Revised 2021-02-09
Further Info :

Pubmed ID

32283212

DOI: Digital Object Identifier

10.1016/j.ejpb.2020.03.021

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SNS
PICO Info
in preparation
Languages

English

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