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Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph<sup>+</sup> Leukemia Cells.
Author: JinRun-Ming, LiKun, LuKe, LvXue-Yan, ShenYa-Qing, WangZhu-Jun, WenYu-Xi, XuWen-Fu
Original Abstract of the Article :
Imatinib mesylate (IM) is the first-line treatment for Philadelphia (Ph) chromosomal positive leukemia by inhibiting phosphorylation of substrates via binding to the ABL kinase domain. Because of the drug resistance, side effects and the high cost of IM, it is necessary to find anti-cancer drugs wit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1007/s11596-020-2181-5
データ提供：米国国立医学図書館（NLM）
Huai Qi Huang: A Potential Treatment for Philadelphia Chromosomal Positive Leukemia
Philadelphia chromosomal positive (Ph+) leukemia is a type of cancer characterized by a specific genetic abnormality. This study explores the potential therapeutic effects of Huai Qi Huang (HQH), a traditional Chinese medicine, in treating Ph+ leukemia cells. The researchers investigated the effects of HQH on the survival and apoptosis (programmed cell death) of leukemia cells, particularly focusing on its impact on the RAF/MEK/ERK signaling pathway.
Huai Qi Huang's Potential Anti-Cancer Activity
The study found that HQH significantly inhibited the survival of Ph+ leukemia cells and promoted their apoptosis in a dose-dependent manner. The researchers observed that HQH downregulated the expression of certain proteins involved in the RAF/MEK/ERK signaling pathway, which plays a crucial role in cell growth and survival. These findings suggest that HQH may have potential anti-cancer activity against Ph+ leukemia.
Exploring Traditional Chinese Medicine for Cancer Treatment
This study highlights the potential of traditional Chinese medicine in treating cancer. The findings suggest that HQH may hold promise as a therapeutic agent for Ph+ leukemia, offering a potential alternative or adjunct treatment option to conventional therapies. Further research is needed to validate these findings and explore the potential of HQH in clinical settings.
Dr. Camel's Conclusion
Just as a camel draws strength and sustenance from the desert's natural remedies, we can learn from the vast and ancient wisdom of traditional Chinese medicine. This study sheds light on the potential of Huai Qi Huang in treating Ph+ leukemia, suggesting a new avenue for cancer research and treatment. By embracing the wisdom of traditional medicine and combining it with modern scientific approaches, we can work towards developing innovative treatments and improving the lives of individuals facing cancer.
Date :
- Date Completed 2021-01-27
- Date Revised 2021-01-27
Further Info :
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