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A New Paradigm for Achieving a Rapid Antidepressant Response.

Author: BellErica, HamiltonAmber, MalhiGin S, MorrisGrace

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article proposes a new paradigm for understanding how antidepressants work. This paradigm suggests that different antidepressants work at different times after starting treatment. This understanding could help guide the development of new antidepressants and lead to faster relief from symptoms.
Paper Details　
Original Abstract of the Article :
The substantive delay (often 4-6 weeks) between the commencement of an antidepressant and any discernible improvement in depressive symptoms is an ongoing concern in the management of depressive disorders. This delay incurs the risk of cessation of medication, self-harm/suicide and ongoing 'damage' ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1007/s40265-020-01303-1

データ提供：米国国立医学図書館（NLM）

A New Paradigm for Speeding Up Antidepressant Response: Windows of Opportunity

The delay in response to antidepressants is a common challenge in treating depression. This research proposes a new paradigm for understanding and achieving a more rapid antidepressant response. It's like mapping a new desert route, identifying different stages in the journey to recovery.

The study defines three distinct 'windows of response' - immediate, fast, and slow - based on the time frame for expected improvement. This is like understanding the different stages of a desert caravan's journey, recognizing the varying challenges and opportunities along the way.

The study suggests that newer agents like rapid-acting antidepressants act within the immediate window, while atypical antipsychotic augmentation strategies fall within the fast window. Conventional antidepressant monotherapy, on the other hand, typically falls within the slow window. This is like choosing the appropriate transportation for a desert journey, recognizing that different vehicles are best suited for different terrains.

A More Efficient Desert Journey

This research offers a novel approach to understanding and addressing the delay in antidepressant response. It's like discovering a new oasis in the desert, providing a more efficient and effective way to navigate the challenges of depression.

Unlocking the Potential of Antidepressants

The study encourages further research into developing new antidepressant agents and treatment strategies that target specific windows of response. It's like exploring new desert pathways, seeking innovative solutions to address the complexities of depression.

Dr.Camel's Conclusion

This research offers a fresh perspective on antidepressant treatment, emphasizing the importance of understanding the different stages of response and tailoring treatment accordingly. It's a reminder that the desert of mental health research continues to evolve, and new discoveries are constantly emerging, providing hope for a more effective and efficient journey to recovery.

Date :
  1. Date Completed 2020-12-30
  2. Date Revised 2020-12-30
Further Info :

Pubmed ID

32347475

DOI: Digital Object Identifier

10.1007/s40265-020-01303-1

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Languages

English

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