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<i>In Vitro</i> and <i>In Vivo</i> Effects of the Polymyxin-Vorinostat Combination Therapy Against Multidrug-Resistant Gram-Negative Pathogens.

Author: ChenHaoran, LiHongru, LiJiabin, LiuZhou

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of combining the antibiotic polymyxin B with the drug vorinostat to treat multidrug-resistant (MDR) bacteria. The combination was found to be more effective than polymyxin B alone, suggesting that this combination therapy may be a promising approach for treating MDR infections.
Paper Details　
Original Abstract of the Article :
With the stagnancy of antibiotics development, polymyxins have become the last defense for treatment of multidrug-resistant (MDR) Gram-negative bacteria, whereas the effect of polymyxin monotherapy is limited by resistance. The objective of this study was to evaluate the effects of polymyxin B (PMNB...See full text at original site
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引用元：
https://doi.org/10.1089/mdr.2019.0309

データ提供：米国国立医学図書館（NLM）

Polymyxin-Vorinostat: A New Weapon in the Desert of Antibiotic Resistance

The rise of antibiotic resistance poses a significant threat to global health. This study explores the potential of a combination therapy using polymyxin B (PMNB) and vorinostat (SAHA) to combat multidrug-resistant (MDR) Gram-negative bacteria. The authors investigate the synergistic effects of this combination, exploring its potential for treating infections caused by these highly resistant pathogens.

A Synergistic Alliance in the Desert

The study demonstrates the synergistic effects of PMNB-SAHA combination therapy against MDR Gram-negative bacteria. This combination showed a significant reduction in bacterial growth compared to either drug alone. The authors also highlight the potential mechanisms of action, including disruption of bacterial cell membranes and increased oxidative stress.

A Promising Solution in the Desert

This study offers a glimmer of hope in the fight against antibiotic resistance, highlighting the potential of PMNB-SAHA combination therapy as a promising new weapon in the battle against MDR Gram-negative bacteria. It's like finding a hidden oasis in the desert of antibiotic resistance, offering a potential path towards more effective treatment strategies.

Dr. Camel's Conclusion

This study presents a compelling case for exploring PMNB-SAHA combination therapy as a potential solution to the growing challenge of antibiotic resistance. The synergistic effects of this combination offer a glimmer of hope in the desert of antibiotic resistance, suggesting a potential path towards more effective treatment strategies for these challenging infections.

Date :
  1. Date Completed 2021-07-02
  2. Date Revised 2021-07-02
Further Info :

Pubmed ID

32349617

DOI: Digital Object Identifier

10.1089/mdr.2019.0309

Related Literature

Article Analysis
・Effects of vorinostat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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