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Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies.

Author: EleftheriouGeorgios, PellacaniClaudia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the neurotoxic side effects of common cancer drugs. Neurotoxicity can affect the central and/or peripheral nervous system. The severity of neurotoxicity is related to the dose, duration, and intensity of treatment, and may be influenced by factors such as age, pre-existing conditions, and genetic predisposition. Neuroprotective strategies may help to reduce the risk and severity of neurotoxicity.
Paper Details　
Original Abstract of the Article :
This review summarizes the adverse effects on the central and/or peripheral nervous systems that may occur in response to antineoplastic drugs. In particular, we describe the neurotoxic side effects of the most commonly used drugs, such as platinum compounds, doxorubicin, ifosfamide, 5-fluorouracil,...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/j.advms.2020.04.001

データ提供：米国国立医学図書館（NLM）

Navigating the Neurotoxic Terrain of Cancer Treatment

Cancer treatment often involves powerful drugs that can have side effects, including neurotoxicity. This research, published in 2019, provides a comprehensive overview of the neurotoxic effects of antineoplastic drugs, highlighting the challenges of balancing therapeutic efficacy with potential side effects. It's like navigating a treacherous desert landscape, where the path to healing can be fraught with unexpected obstacles. This review focuses on the neurotoxic effects of commonly used chemotherapy drugs and explores the potential for neuroprotective strategies.

Understanding the Mechanisms of Neurotoxicity

The research delves into the mechanisms by which these drugs can damage the nervous system, either directly or indirectly. This is like understanding the intricate workings of a desert ecosystem, where each element interacts with the others to create a complex network of effects. The review highlights the importance of considering factors like dose, duration of treatment, and individual patient characteristics in assessing the risk of neurotoxicity.

Protecting the Nervous System

This research explores the potential of neuroprotective compounds and strategies to mitigate the risk of neurotoxicity. These strategies, like finding a safe oasis in the desert, aim to reduce the negative impact of chemotherapy on the nervous system, enabling patients to receive the necessary treatment without experiencing debilitating side effects.

Dr.Camel's Conclusion

This research is a reminder that even in the face of powerful therapies, we must be mindful of the potential for unintended consequences. It highlights the importance of ongoing research into neuroprotective strategies, like seeking a safe haven in the desert, to improve the lives of cancer patients. It's a testament to our commitment to finding better ways to combat this devastating disease while safeguarding the delicate balance of our bodies.

Date :
  1. Date Completed 2021-09-03
  2. Date Revised 2021-09-03
Further Info :

Pubmed ID

32361484

DOI: Digital Object Identifier

10.1016/j.advms.2020.04.001

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English

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