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Selexipag for the treatment of children with pulmonary arterial hypertension: First multicenter experience in drug safety and efficacy.
Author: , BukovaMila, ChouvarinePhilippe, HansmannGeorg, KoestenbergerMartin, MeinelKatharina, WåhlanderHåkan
Original Abstract of the Article :
BACKGROUND: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN) investigated the safety and efficacy of add-on selexipag, an oral prostacyclin receptor agonist approved for pulmonary arterial hypertension (PAH) in adults, in the largest, exploratory pediatric cohort to date. METHODS:...See full text at original site
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引用元:
https://doi.org/10.1016/j.healun.2020.03.029
データ提供:米国国立医学図書館(NLM)
Selexipag: A New Hope for Children with Pulmonary Arterial Hypertension
This multicenter study investigates the safety and efficacy of [selexipag], an oral prostacyclin receptor agonist, as an add-on therapy for children with pulmonary arterial hypertension (PAH). The authors provide a comprehensive analysis of the drug's safety profile and its impact on various clinical parameters, including right atrial pressure, pulmonary arterial pressure, and transpulmonary pressure gradients. This study highlights the potential of selexipag as a valuable treatment option for children with PAH, offering hope for improved outcomes and potentially delaying the need for lung transplantation.
Selexipag: A Promising Addition to PAH Treatment
The study reveals the potential of selexipag, an oral prostacyclin receptor agonist, as a safe and well-tolerated add-on therapy for children with PAH. The researchers observed improvements in several key clinical parameters, including right atrial pressure, pulmonary arterial pressure, and transpulmonary pressure gradients, suggesting that selexipag may contribute to improved hemodynamics and potentially delay disease progression. This finding offers hope for improved outcomes and potentially delayed need for lung transplantation in children with PAH. The study encourages further research into the long-term efficacy and safety of selexipag in children with PAH, seeking to optimize treatment strategies and improve patient outcomes.
Understanding the Implications for PAH Treatment
The study underscores the importance of developing effective and safe treatment options for children with PAH, a debilitating condition that often requires complex management strategies. The findings highlight the potential of selexipag, an oral prostacyclin receptor agonist, as a valuable addition to existing treatment regimens. This research encourages further research into the long-term efficacy and safety of selexipag in children with PAH, seeking to optimize treatment strategies and improve patient outcomes.
Dr.Camel's Conclusion
This research reminds us that even in the vast desert of PAH treatment, where challenges abound, there is always hope for a better future. The study's findings suggest that selexipag may offer a promising path toward improved outcomes and potentially delayed need for lung transplantation for children with this challenging condition. This research encourages continued exploration of selexipag's potential in PAH treatment, seeking to optimize treatment strategies and improve patient outcomes.
Date :
- Date Completed 2021-07-05
- Date Revised 2021-07-05
Further Info :
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