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Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review.

Author: CalinaDaniela, DoceaAnca Oana, FragkiadoulakiIrene, GeorgiadisGeorgios, KaravitakisMarkos, MamoulakisCharalampos, MavridisCharalampos, SofikitisNikolaos, StratakisStavros, StylianouKostas, TsarouhasKonstantinos, TsatsakisAristidis, TsitsimpikouChristina, ZisisIoannis-Erineos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of phosphodiesterase 5 inhibitors (PDE5Is) for protecting the kidneys from damage. PDE5Is are currently used to treat erectile dysfunction. Animal studies have shown that PDE5Is can protect the kidneys from damage in various forms of kidney injury. However, more human studies are needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is), currently available as first-line therapy of erectile dysfunction in humans, have shown a beneficial potential of ren...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287956/

データ提供：米国国立医学図書館（NLM）

Phosphodiesterase 5 Inhibitors and Reno-Protective Effects in Acute Kidney Injury

This systematic review delves into the intriguing world of [acute kidney injury (AKI)] and explores the potential renoprotective effects of [phosphodiesterase 5 inhibitors (PDE5Is)]. The review summarizes the growing body of research on PDE5Is, a class of drugs primarily used for [erectile dysfunction]. The authors conducted a comprehensive analysis of [83 studies] to evaluate the evidence for PDE5Is' renoprotective properties in various forms of AKI. Their analysis highlights the potential of PDE5Is to improve renal function and mitigate AKI-related complications, primarily through mechanisms that impact [regional hemodynamics, cell expression, and mitochondrial response to oxidative stress and inflammation].

Navigating the Sands of AKI

This systematic review suggests that PDE5Is may play a role in protecting the kidneys from damage in the context of AKI. Imagine a desert oasis, a source of life-giving water amidst the harsh landscape. Similarly, PDE5Is might act as a protective force, mitigating the damage caused by AKI and preserving kidney function. This research offers a promising glimpse into the potential of these drugs for improving patient outcomes.

Protecting the Oasis of Kidney Health

This review highlights the importance of exploring new avenues for preventing and managing AKI. Just as we strive to protect precious oases in the desert, we must prioritize the health of our kidneys. Understanding the potential renoprotective effects of PDE5Is can guide us towards developing effective strategies for preserving kidney function and mitigating the risks associated with AKI.

Dr.Camel's Conclusion

This systematic review provides compelling evidence for the potential renoprotective effects of PDE5Is. It serves as a reminder that the desert of scientific inquiry is vast, and we must continually explore new avenues to discover innovative solutions for challenging health conditions.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

32365529

DOI: Digital Object Identifier

PMC7287956

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English

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