N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease.

Author: AndradeVíctor, CortésNicole, GonzalezAndrea, MaccioniRicardo B, PasteneEdgar, PastorGabriela, Ramos-EscobarNicolás, RojoLeonel E

Paper Details 
Original Abstract of the Article :
Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free radicals, and other molecules that promotes neuroinflammation in the brain, promoting neuron...See full text at original site
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引用元:
https://doi.org/10.3233/JAD-200067

データ提供:米国国立医学図書館(NLM)

Multi-Target Compounds: A Novel Approach to Alzheimer's Disease

This article explores the potential of multi-target compounds, specifically N-acetylcysteine (NAC) and catechin-derived polyphenols, as a novel therapeutic approach for Alzheimer's disease (AD). The authors explain the multifactorial nature of AD, highlighting the role of neuroinflammation and the involvement of microglial cells in promoting neuronal death. They discuss the promising evidence suggesting that NAC and epicatechin-derived polyphenols from tea may exert neuroprotective effects through various mechanisms, including modulation of neuroinflammation, reduction of oxidative stress, and promotion of cognitive function.

A New Oasis in the Desert of Alzheimer's Research: Multi-Target Therapy

This article highlights the potential of multi-target therapy, using compounds like NAC and epicatechin-derived polyphenols, to address the complex challenges of Alzheimer's disease. The authors' comprehensive analysis of the existing research underscores the potential of these compounds to offer a more holistic and effective approach to managing this debilitating disease.

Navigating the Desert of Alzheimer's Treatment

Finding effective treatments for Alzheimer's disease can feel like searching for a life-giving oasis in the desert. This article offers a ray of hope, exploring the potential of multi-target compounds to combat the disease's multifaceted nature and offer a more promising path toward improved outcomes.

Dr. Camel's Conclusion

This insightful article explores the promising potential of multi-target compounds in the fight against Alzheimer's disease. The authors' exploration of the complex mechanisms underlying these compounds' effects offers valuable insights into a potential new frontier in Alzheimer's research and treatment.

Date :
  1. Date Completed 2021-05-13
  2. Date Revised 2021-05-13
Further Info :

Pubmed ID

32390631

DOI: Digital Object Identifier

10.3233/JAD-200067

Related Literature

SNS
PICO Info
in preparation
Languages

English

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