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The derived-band envelope following response and its sensitivity to sensorineural hearing deficits.

Author: GarrettMarkus, KeshishzadehSarineh, VasilkovViacheslav, VerhulstSarah

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study introduced a new technique called derived-band EFR (DBEFR) to improve frequency specificity of the envelope following response (EFR) and investigated the effect of noise exposure, age, and outer-hair-cell (OHC) damage on DBEFR magnitudes. The combined analysis of simulations and experimental data showed that DBEFRs extracted from the [2-6]-kHz frequency band is a sensitive and frequency-specific measure of synaptopathy in humans. The study also found that lifetime noise exposure and age-induced synaptopathy affect DBEFR magnitudes.
Paper Details　
Original Abstract of the Article :
The envelope following response (EFR) has been proposed as a non-invasive marker of synaptopathy in animal models. However, its amplitude is affected by the spread of basilar-membrane excitation and other coexisting sensorineural hearing deficits. This study aims to (i) improve frequency specificity...See full text at original site
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引用元：
https://doi.org/10.1016/j.heares.2020.107979

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of Synaptopathy with the Derived-Band Envelope Following Response

The study explores a novel approach to understanding [synaptopathy], a crucial aspect of [hearing loss], by introducing the [derived-band EFR] technique. The study investigates the sensitivity of this technique to various factors, including [lifetime noise exposure], [age], and [outer-hair-cell damage]. The research utilizes both experimental data and a sophisticated modeling approach to validate the frequency-specificity of the [DBEFR] and to uncover how different aspects of [sensorineural hearing loss] impact the peripheral generators of the [EFR].

The Promise of DBEFR for Synaptopathy Diagnosis

The study's findings suggest that the [DBEFR], particularly in the [2-6]-kHz frequency band, holds great promise as a sensitive and frequency-specific measure of [synaptopathy] in humans. The study also unveils the influence of [lifetime noise exposure], [age], and [outer-hair-cell damage] on DBEFR magnitudes, adding further depth to our understanding of [hearing loss].

Health Implications and Lifestyle Recommendations

This research underscores the importance of protecting our hearing from excessive noise exposure and managing age-related hearing changes. It also highlights the need for further research to develop effective treatments for [synaptopathy] and to improve our understanding of the complex mechanisms underlying [hearing loss].

Dr.Camel's Conclusion

The [DBEFR] technique offers a promising avenue for exploring [synaptopathy] in humans, paving the way for a more precise diagnosis of hearing loss and potentially leading to more effective treatment strategies. The study underscores the importance of early detection and preventive measures to protect hearing and to manage age-related hearing changes.

Date :
  1. Date Completed 2021-08-23
  2. Date Revised 2021-08-23
Further Info :

Pubmed ID

32447097

DOI: Digital Object Identifier

10.1016/j.heares.2020.107979

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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