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Abacavir adverse reactions related with HLA-B*57: 01 haplotype in a large cohort of patients infected with HIV.
Author: CarellaGraziella, CastelliFrancesco, FerraresiAlice, FocàEmanuele, GardiniGiulia, MalagoliAlberto, MarchiAlessandro, ProperziMartina, Quiros-RoldanEugenia
Original Abstract of the Article :
Carriage of human leukocyte antigen (HLA)-B*57:01 allele increases the risk of abacavir hypersensitivity reaction. Therefore, since 2008 HIV treatment guidelines recommend HLA-B*57:01 screening before abacavir administration, greatly reducing hypersensitivity reaction rate. However, clinically suspe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32453265
データ提供：米国国立医学図書館（NLM）
Abacavir and HLA-B*57:01: A Complex Interaction
Abacavir, a medication used to treat HIV infection, is a powerful tool, but its use is not without risks. This study, like a skilled detective investigating a complex case, explores the relationship between abacavir and the HLA-B*57:01 haplotype, a genetic marker that can increase the risk of adverse reactions. The researchers, with their genetic expertise and clinical knowledge, delve into the complex interplay between these two factors. Their findings, like a map of a treacherous desert landscape, highlight the importance of screening for HLA-B*57:01 before administering abacavir to HIV-infected individuals.
Screening for HLA-B*57:01: A Crucial Step
The study underscores the significance of HLA-B*57:01 screening before abacavir treatment. This screening, like a compass in the desert, can help identify individuals at increased risk of adverse reactions and guide treatment decisions. The findings, like a desert oasis offering safety and security, emphasize the importance of preventive measures to minimize the risk of adverse drug reactions.
Understanding Drug Interactions: Navigating the Desert of Medicine
The study provides a valuable reminder of the complex interactions between medications and individual genetic makeup. This knowledge, like a map leading to a hidden oasis, is crucial for safe and effective medical treatment. Understanding drug interactions, like a skilled desert guide, can help navigate the intricate landscape of medicine and ensure a smoother journey for patients.
Dr.Camel's Conclusion
Abacavir, a powerful weapon in the fight against HIV, can be a double-edged sword. This study, like a beacon in a desert, sheds light on the importance of HLA-B*57:01 screening before administering abacavir. This screening, like a compass guiding a traveler, can help minimize the risk of adverse reactions and ensure a safer path for those seeking treatment.
Date :
- Date Completed 2021-03-08
- Date Revised 2021-03-08
Further Info :
Related Literature
English
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