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Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease.
Author: AhnJaeil, AnjumMuhammad, BerkowitzFrank, EspositoGiuseppe, FerranteDalila, HebronMichaeline L, JiangXiong, LawlerAbigail, LiuXiaoguang, MatarSara, MoussaCharbel, MulkiSanjana, MundelElizabeth E, PaganFernando, ShiWangke, StarrJ Nathan, Torres-YaghiYasar, TurnerRaymond S, YusufNadia
Original Abstract of the Article :
Preclinical evidence with nilotinib, a US Food and Drug Administration (FDA)-approved drug for leukemia, indicates improvement in Alzheimer's disease phenotypes. We investigated whether nilotinib is safe, and detectable in cerebrospinal fluid, and alters biomarkers and clinical decline in Alzheimer'...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383852/
データ提供:米国国立医学図書館(NLM)
Nilotinib: A Potential Therapeutic for Alzheimer's Disease?
Alzheimer's disease, a devastating neurodegenerative disorder, presents a significant challenge in the field of medicine. This research explores the potential therapeutic benefits of nilotinib, a US Food and Drug Administration (FDA)-approved drug for leukemia, in treating Alzheimer's disease. Drawing on preclinical evidence suggesting improvements in Alzheimer's disease phenotypes, the authors investigate the safety, cerebrospinal fluid penetration, biomarker effects, and clinical impact of nilotinib in patients with Alzheimer's disease. The study aims to determine whether nilotinib is safe, detectable in the cerebrospinal fluid, and capable of altering biomarkers and slowing clinical decline in Alzheimer's disease. The findings provide valuable insights into the potential of nilotinib as a novel therapeutic for Alzheimer's disease.Nilotinib: A Potential New Weapon in the Fight Against Alzheimer's Disease
The study's findings present nilotinib as a potential therapeutic agent for Alzheimer's disease. While further research is needed to confirm its efficacy, the study's findings suggest that nilotinib may be safe, capable of reaching the brain, and potentially capable of altering biomarkers associated with Alzheimer's disease. This research offers hope for the development of novel therapies to combat this devastating neurodegenerative disorder, providing a potential new avenue for treating Alzheimer's disease.Nilotinib: A Call for Further Research and Clinical Trials
The study's findings highlight the need for further research and clinical trials to fully evaluate the potential of nilotinib as a therapeutic for Alzheimer's disease. While the study's initial findings are promising, more extensive research is necessary to confirm its efficacy, determine optimal dosing strategies, and assess long-term safety and efficacy. This research serves as a crucial step forward in the search for effective treatments for Alzheimer's disease, providing a strong foundation for future investigations.Dr. Camel's Conclusion
This research embarks on a promising journey into the potential of nilotinib as a therapeutic for Alzheimer's disease. Like a camel traversing the vast desert, seeking an oasis of hope, researchers are diligently exploring new pathways to combat this debilitating disease. While the study's findings offer a glimmer of hope, further research is essential to validate the potential of nilotinib as a truly effective treatment for Alzheimer's disease.Date :
- Date Completed 2020-10-13
- Date Revised 2022-01-14
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