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Testicular pain following initiation of elexacaftor/tezacaftor/ivacaftor in males with cystic fibrosis.

Author: DuehlmeyerStephanie, HeckmanBrian, JacobsHollyann R, RotoloShannon M, SlackSarah M

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Elexacaftor/tezacaftor/ivacaftor (Trikafta) may cause testicular pain in some male patients with cystic fibrosis. This side effect typically resolves within a week and further research is needed to understand its long-term impact on fertility.
Paper Details　
Original Abstract of the Article :
Elexacaftor/tezacaftor/ivacaftor (Trikafta) was approved by the Food and Drug Administration in October 2019 for treatment of cystic fibrosis (CF) in patients 12 years and older with at least one F508del mutation in the CFTR protein. There were no documented reports of testicular pain during clinica...See full text at original site
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引用元：
https://doi.org/10.1016/j.jcf.2020.04.017

データ提供：米国国立医学図書館（NLM）

Testicular Pain Following Initiation of Elexacaftor/Tezacaftor/Ivacaftor in Males with Cystic Fibrosis

This case series explores the occurrence of testicular pain in seven males with cystic fibrosis (CF) after initiating treatment with elexacaftor/tezacaftor/ivacaftor (Trikafta). While clinical trials did not document testicular pain as a side effect, these patients experienced this symptom within the first two weeks of starting Trikafta. The authors speculate that the pain might be related to the restored function of the CFTR protein in the male reproductive tract.

Unforeseen Side Effects: A Desert of Uncertainty

While Trikafta has shown significant promise in treating CF, this case series highlights a potential side effect that needs further investigation. The authors caution that the mechanism of this side effect is unknown and requires further research. They also recommend counseling patients on contraceptive options until more data is available.

Navigating the Landscape of New Treatments

It's like exploring a new desert landscape, where the terrain is constantly shifting and surprises can emerge at every turn. Just as a camel must adapt to its surroundings, we must constantly learn and adapt to new treatments and their potential side effects. While Trikafta offers hope for CF patients, it's important to remain vigilant and continue to monitor its long-term impact, ensuring that the benefits outweigh the risks. By learning from these experiences, we can optimize the use of new treatments and ensure the safety and well-being of all patients.

Dr.Camel's Conclusion

This case series highlights the importance of ongoing surveillance for potential side effects of new treatments, even those that have shown promise in clinical trials. The authors' findings underscore the need for further research to understand the mechanism of this side effect and its long-term implications. This information will be crucial for guiding clinical decision-making and ensuring the safety and well-being of patients receiving Trikafta.

Date :
  1. Date Completed 2021-10-19
  2. Date Revised 2021-11-16
Further Info :

Pubmed ID

32471772

DOI: Digital Object Identifier

10.1016/j.jcf.2020.04.017

SNS
PICO Info
in preparation
Languages

English

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