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Comparative Effectiveness of Calcimimetic Agents for Secondary Hyperparathyroidism in Adults: A Systematic Review and Network Meta-analysis.

Author: JohnsonDavid W, MavridisDimitris, PalmerSuetonia C, RuospoMarinella, StrippoliGiovanni F M, TonelliMarcello

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Calcimimetic agents were more effective than placebo in reducing serum parathyroid hormone (PTH) levels in patients with chronic kidney disease. Etelcalcetide was associated with the largest reduction in PTH levels, but also caused more hypocalcemia and nausea than cinacalcet or evocalcet.
Paper Details　
Original Abstract of the Article :
RATIONALE & OBJECTIVE: Comparative benefits and harms of calcimimetic agents used for the treatment of secondary hyperparathyroidism have not been well characterized. We sought to compare the effectiveness of 3 calcimimetic agents using published data. STUDY DESIGN: Systematic review of randomized ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1053/j.ajkd.2020.02.439

データ提供：米国国立医学図書館（NLM）

Navigating the Choices for Secondary Hyperparathyroidism: Comparing Calcimimetic Agents

Secondary hyperparathyroidism, a common complication of chronic kidney disease, presents a significant challenge for healthcare providers. This study delves into the world of calcimimetic agents, comparing their effectiveness and safety in managing this complex condition. Researchers conducted a comprehensive systematic review and network meta-analysis to assess the comparative benefits and harms of three calcimimetic agents: cinacalcet, etelcalcetide, and evocalcet.

Etelcalcetide Emerges as the Most Effective Calcimimetic Agent

The study's findings suggest that etelcalcetide is the most effective calcimimetic agent in achieving target parathyroid hormone (PTH) levels compared to cinacalcet and evocalcet. However, researchers also noted that etelcalcetide was associated with a higher risk of hypocalcemia compared to other calcimimetic agents.

Tailoring Treatment Strategies for Secondary Hyperparathyroidism

This study provides valuable information for clinicians managing patients with secondary hyperparathyroidism. The study's findings offer a comparative analysis of three calcimimetic agents, highlighting the strengths and weaknesses of each. The study underscores the importance of carefully considering the individual patient's needs and potential risks when selecting the most appropriate calcimimetic agent.

Dr.Camel's Conclusion

This study sheds light on the efficacy and safety profiles of calcimimetic agents in managing secondary hyperparathyroidism. The findings suggest that etelcalcetide may be the most effective agent in achieving PTH targets, but it also carries a higher risk of hypocalcemia. The study emphasizes the need for careful patient selection and monitoring to minimize potential side effects and ensure optimal outcomes.

Date :
  1. Date Completed 2020-10-08
  2. Date Revised 2020-10-08
Further Info :

Pubmed ID

32475604

DOI: Digital Object Identifier

10.1053/j.ajkd.2020.02.439

Related Literature

Article Analysis
・Side Effects of cinacalcet
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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