Ocular side effects of target therapy and immunotherapy in patients with cutaneous malignant melanoma.

Author: DenneyDerek, EikenberryJennifer, HarrisAlon, LangMatthew, SieskyBrent, TorabiRana, Verticchio VercellinAlice

Paper Details 
Original Abstract of the Article :
To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanom...See full text at original site
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引用元:
https://doi.org/10.1177/1120672120930688

データ提供:米国国立医学図書館(NLM)

Ocular Side Effects of Melanoma Therapies: Navigating the Desert of Side Effects

The quest to conquer melanoma, a formidable adversary in the battle against cancer, is a journey through a vast and complex desert landscape. This study, a guidepost in the desert of melanoma treatment, delves into the potential ocular side effects of novel therapies, shedding light on an often-overlooked aspect of treatment. The authors investigated the nature and frequency of ocular side effects associated with targeted therapies using BRAF and MEK inhibitors, and immunotherapy using CTLA-4 and PD-1 monoclonal antibodies in patients with cutaneous malignant melanoma (CMM). Their findings reveal that while these therapies offer significant benefits, they can also come with potential ocular complications.

Ocular Side Effects: A Challenge in Melanoma Treatment

The study's findings highlight the importance of monitoring for ocular side effects in patients receiving targeted and immunotherapy for melanoma. The authors found that these therapies can lead to a range of ocular complications, including conjunctivitis (inflammation of the conjunctiva), uveitis (inflammation of the uvea), and dry eye disease. The study underscores the need for a vigilant approach to monitoring for ocular side effects, ensuring prompt identification and management to minimize potential vision impairment.

Melanoma Treatment: Balancing Benefits and Risks

The study emphasizes the importance of balancing the potential benefits and risks of melanoma treatments. While these therapies offer significant hope for patients, it's crucial to be aware of the potential side effects, including ocular complications. The researchers highlight the importance of regular eye examinations and prompt attention to any visual disturbances or discomfort, allowing for early intervention and potentially minimizing the impact of side effects. The study encourages a collaborative approach between oncologists and ophthalmologists to ensure optimal patient care and minimize the risk of long-term vision impairment.

Dr.Camel's Conclusion

The desert of melanoma treatment is a challenging and complex landscape, with potentially difficult side effects. This study, a compass guiding us through this terrain, highlights the importance of vigilant monitoring for ocular complications. By understanding the potential risks and collaborating closely with ophthalmologists, we can navigate this path more effectively and provide the best possible care for patients undergoing melanoma treatment.

Date :
  1. Date Completed 2021-08-19
  2. Date Revised 2022-04-25
Further Info :

Pubmed ID

32476450

DOI: Digital Object Identifier

10.1177/1120672120930688

Related Literature

SNS
PICO Info
in preparation
Languages

English

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