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Efficacy and Safety of Peripherally Acting Mu-Opioid Receptor Antagonists for the Treatment of Opioid-Induced Constipation: A Bayesian Network Meta-analysis.

Author: HuangJiean, HuangShijiang, LiZhongzhuan, LiuJun, OuyangRong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Peripherally acting mu-opioid receptor antagonists (PAMORAs) are effective and safe for the treatment of opioid-induced constipation (OIC). A network meta-analysis of randomized controlled trials found that naldemedine and naloxone were the most effective PAMORAs, showing a better bowel movement response than placebo.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess the efficacy and safety of peripherally acting mu-opioid receptor antagonists (PAMORAs) for the treatment of opioid-induced constipation (OIC). METHODS: Randomized controlled trials (RCTs) were searched for OIC therapy comparing PAMORAs with placebo. Both a pairwise and network...See full text at original site
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引用元：
https://doi.org/10.1093/pm/pnaa152

データ提供：米国国立医学図書館（NLM）

The Quest for Relief: Peripherally Acting Mu-Opioid Receptor Antagonists for Opioid-Induced Constipation

This research dives into the desert of opioid-induced constipation, a common side effect that can make life feel like a never-ending sandstorm. The study focuses on peripherally acting mu-opioid receptor antagonists (PAMORAs), which act like oasis in this arid landscape, providing relief by counteracting the constipating effects of opioids. The researchers used a rigorous approach, a combination of pairwise and network meta-analysis, to compare the effectiveness and safety of different PAMORAs. They found that PAMORAs were indeed effective and safe, with naldemedine and naloxone emerging as the most promising candidates for treating opioid-induced constipation.

Naldemedine and Naloxone: Leading the Way in Opioid-Induced Constipation Treatment

The researchers discovered that naldemedine and naloxone were the most effective PAMORAs in treating opioid-induced constipation. Naldemedine, with a SUCRA score of 89.42%, followed by naloxone with a SUCRA score of 87.44%, were found to significantly improve the frequency of bowel movements compared to a placebo. This discovery could be a beacon of hope for patients struggling with this debilitating condition.

Navigating the Opioid Desert: Health Implications and Practical Tips

These findings suggest that PAMORAs, especially naldemedine and naloxone, could be a valuable tool in managing opioid-induced constipation. However, it's essential to consult a healthcare professional before starting any new treatment. You can also explore lifestyle changes like increasing fiber intake and staying hydrated to further promote regularity.

Dr.Camel's Conclusion

The researchers conducted a fascinating study that sheds light on the potential of PAMORAs, particularly naldemedine and naloxone, for treating opioid-induced constipation. This research could lead to improved quality of life for patients experiencing this common side effect. Remember, navigating the desert of opioid-induced constipation can be challenging, but with the right knowledge and support, relief is within reach.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

32488259

DOI: Digital Object Identifier

10.1093/pm/pnaa152

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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