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Risk Factors and Prevention of Pneumocystis jirovecii Pneumonia in Patients With Autoimmune and Inflammatory Diseases.

Author: CacoubPatrice, GhembazaAmine, PourcherValérie, SaadounDavid, VautierMathieu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Patients with autoimmune and/or inflammatory diseases are at a higher risk of developing Pneumocystis jirovecii pneumonia (PJP). This review discusses the epidemiology, risk factors, and prevention of pneumocystis in the context of autoimmune diseases. Trimethoprim-sulfamethoxazole is considered first-line therapy for PJP prophylaxis, but atovaquone or aerosolized pentamidine can be used when trimethoprim-sulfamethoxazole is not tolerated.
Paper Details　
Original Abstract of the Article :
Patients with autoimmune and/or inflammatory diseases (AIIDs) are prone to serious infectious complications such as Pneumocystis jirovecii pneumonia (PJP). In non-HIV patients, the prognosis is poorer, and diagnostic tests are of lower sensitivity. Given the low incidence of PJP in AIIDs, with the e...See full text at original site
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引用元：
https://doi.org/10.1016/j.chest.2020.05.558

データ提供：米国国立医学図書館（NLM）

Pneumocystis Jirovecii Pneumonia: A Desert of Vulnerability for Immune-Compromised Patients

This research explores the vast and often perilous landscape of Pneumocystis jirovecii pneumonia (PJP), a serious infectious complication that can pose a significant threat to individuals with autoimmune and/or inflammatory diseases (AIIDs). The study delves into the epidemiology, risk factors, and prevention strategies for PJP in the context of AIIDs, highlighting the vulnerability of these individuals and the need for proactive measures to mitigate this risk.

The Arid Landscape of PJP: A Threat to Immune-Compromised Patients

This research underscores the vulnerability of individuals with AIIDs to PJP. The study's findings indicate that patients with AIIDs are at an increased risk of developing this serious infectious complication. The study highlights the need for careful monitoring of these patients, particularly those with specific risk factors, and for the implementation of appropriate preventive measures.

Navigating the Desert: Prevention and Management of PJP in AIIDs

The study emphasizes the importance of early detection and prevention strategies to reduce the risk of PJP in AIIDs. It highlights the importance of identifying high-risk individuals and implementing appropriate prophylaxis, such as trimethoprim-sulfamethoxazole, to minimize the risk of infection. The study also emphasizes the need for ongoing research to develop more effective prevention and treatment strategies for PJP in this vulnerable population.

Dr. Camel's Conclusion

This research provides a valuable guide for navigating the arid landscape of PJP in AIIDs. The study underscores the importance of recognizing the increased vulnerability of this population, implementing effective prevention strategies, and being prepared to manage this serious complication. It reminds us that the desert of immune-compromised individuals can be a dangerous place, but with vigilance, early intervention, and ongoing research, we can create a more fertile and protective environment for these patients.

Date :
  1. Date Completed 2021-05-25
  2. Date Revised 2021-05-25
Further Info :

Pubmed ID

32502592

DOI: Digital Object Identifier

10.1016/j.chest.2020.05.558

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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