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Diurnal variation in fentanyl-induced hormone responses and side effects.

Author: AratoM, BagdyG, BankiC M, FeketeM I, FrecskaE, MohariK, PerenyiA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fentanyl, an opioid agonist, produced a significant increase in prolactin and thyrotropin secretion in healthy women. The response was higher in the evening than in the morning, suggesting a diurnal variation in opioid responsiveness.
Paper Details　
Original Abstract of the Article :
The prolactin (PRL) and thyrotropin (TSH) secretory response to the opioid agonist fentanyl (0.1 mg IV) was investigated with serial blood sampling in ten healthy women at 9 AM and 9 PM on different days. In five subjects saline control trials were also performed. A repeated-measures analysis of var...See full text at original site
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引用元：
https://doi.org/10.1016/0893-133x(88)90022-x

データ提供：米国国立医学図書館（NLM）

Diurnal Variation in Fentanyl-Induced Hormone Responses and Side Effects

Fentanyl, a powerful opioid analgesic, is widely used for pain management. However, its effects can vary depending on the time of day, potentially influencing both hormone responses and side effects.

This study investigated the diurnal variation in prolactin and thyrotropin responses to fentanyl administration in healthy women. The researchers found that fentanyl administration resulted in elevated hormone responses in the evening compared to the morning, and subjects reported more drug-related symptoms in the evening.

Time-Dependent Effects of Fentanyl

This study highlights the importance of considering the time of day when administering fentanyl. The study found that fentanyl's effects on hormone responses and side effects can vary significantly depending on the time of day. It's crucial to be aware of these diurnal variations to optimize fentanyl administration and minimize potential complications.

Implications for Pain Management

This research suggests that the timing of fentanyl administration may play a role in its effectiveness and side effects. It highlights the need for individualized approaches to pain management, taking into account potential diurnal variations in drug responses. Further research is needed to fully understand the mechanisms behind these variations and develop strategies for optimizing fentanyl administration for each patient.

Dr.Camel's Conclusion

Fentanyl, like a desert oasis, can offer relief from pain, but its effects can be like the shifting sands, varying depending on the time of day. This study underscores the importance of understanding these variations in drug responses, allowing us to navigate the desert of pain management with greater precision and care. Further research is needed to unravel the mysteries of time-dependent drug effects, enabling us to better tailor treatment plans and optimize patient care.
Date :
  1. Date Completed 1989-08-02
  2. Date Revised 2019-05-15
Further Info :

Pubmed ID

3251504

DOI: Digital Object Identifier

10.1016/0893-133x(88)90022-x

Related Literature

Article Analysis
・Side Effects of fentanyl
SNS
PICO Info
in preparation
Languages

English

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