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Is pasireotide-induced diabetes mellitus predictable? A pilot study on the effect of a single dose of pasireotide on glucose homeostasis.

Author: ArnaldiGiorgio, BarbotMattia, CeccatoFilippo, LizzulLaura, MondinAlessandro, PlebaniMario, RegazzoDaniela, ScaroniCarla, ZaninottoMartina, ZilioMarialuisa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Pasireotide (PAS) is an effective treatment for Cushing's disease (CD) but it can cause diabetes mellitus (DM) in a high number of patients. This study investigated the effect of a single subcutaneous injection of PAS on glucose metabolism in CD and looked for factors that could predict the onset of DM.
Paper Details　
Original Abstract of the Article :
Pasireotide (PAS) is an effective treatment for Cushing's disease (CD) but its use is burdened by an associated high incidence of diabetes mellitus (DM). The aim of this study was to examine the effect of a single subcutaneous injection of PAS on glucose metabolism in CD, and to identify predictors ...See full text at original site
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引用元：
https://doi.org/10.1007/s11102-020-01055-x

データ提供：米国国立医学図書館（NLM）

Predicting Diabetes in the Desert of Cushing's Disease

Cushing's disease, a disorder caused by excessive production of cortisol, can be a challenging desert to navigate, often leading to a range of health complications. This study focuses on pasireotide, a medication used to treat Cushing's disease. However, a significant side effect of pasireotide is the development of diabetes. The researchers sought to determine if there are any factors that can predict the risk of developing diabetes in patients taking pasireotide.

Navigating the Risks in the Desert of Cushing's Disease

The study found that a single dose of pasireotide can have a significant impact on glucose metabolism, highlighting the potential for developing diabetes. While the study did not identify specific predictors of diabetes onset, it provides valuable information about the potential risks associated with pasireotide. This knowledge is crucial for clinicians, as it allows them to monitor patients closely and take proactive steps to manage their glucose levels.

Finding a Path in the Desert

This study provides valuable insights into the challenges of managing Cushing's disease. While pasireotide can be an effective treatment, the potential for developing diabetes is a significant concern. This research underscores the need for careful monitoring and personalized management strategies to help patients navigate the desert of Cushing's disease with greater safety and awareness.

Dr. Camel's Conclusion

This study emphasizes the importance of individualizing treatment approaches in the desert of Cushing's disease. While pasireotide can be a valuable tool, understanding the potential for developing diabetes is crucial for ensuring the best possible outcomes for patients. As we continue to explore the intricacies of this complex disease, we hope to find more effective and safer ways to help patients find a more fulfilling oasis.

Date :
  1. Date Completed 2021-07-19
  2. Date Revised 2021-07-19
Further Info :

Pubmed ID

32524277

DOI: Digital Object Identifier

10.1007/s11102-020-01055-x

Related Literature

Article Analysis
・Effects of pasireotide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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