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Targeting anti-cancer agents to bone using bisphosphonates.

Author: BoeckmanRobert K, BoyceBrendan F, EbetinoFrank H, LiJinbo, SawyerTomi K, SrinivasanVenkat, TaoJianguo, XingLianping, YaoZhenqiang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Bone tumors can weaken bones and increase the risk of fractures. This review discusses the use of bisphosphonates, a class of drugs that target bone, as a way to deliver cancer drugs directly to the tumor site. This approach has shown promising results in preclinical and early clinical trials, demonstrating the potential to improve drug efficacy and reduce side effects.
Paper Details　
Original Abstract of the Article :
The skeleton is affected by numerous primary and metastatic solid and hematopoietic malignant tumors, which can cause localized sites of osteolysis or osteosclerosis that can weaken bones and increase the risk of fractures in affected patients. Chemotherapeutic drugs can eliminate some tumors in bon...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32585321

データ提供：米国国立医学図書館（NLM）

Targeting Anti-Cancer Agents to Bone using Bisphosphonates

This research delves into the realm of [oncology], focusing on the development of new strategies for targeting anti-cancer agents to bone. The study explores the use of bisphosphonates as a delivery mechanism for drugs, aiming to enhance their efficacy and reduce adverse effects in patients with bone tumors. The authors provide a comprehensive review of pre-clinical and clinical studies, highlighting the potential of this approach to treat various bone-related diseases.

The Promise of Bisphosphonate-Based Drug Delivery

The study presents compelling evidence suggesting that conjugating drugs to bisphosphonates can significantly improve drug efficacy and reduce side effects. This approach holds promise for treating diseases like osteoporosis, metastatic bone disease, multiple myeloma, and osteosarcoma. However, despite the encouraging results, the technology faces several challenges, including the need for larger clinical trials and greater pharmaceutical industry involvement.

The Future of Bone-Targeted Drug Delivery

This research offers hope for patients with bone-related diseases, suggesting that bisphosphonate-based drug delivery could revolutionize their treatment. The study highlights the potential of this approach to improve patient outcomes and underscores the importance of continued research in this area. As we continue to explore innovative approaches to cancer treatment, the use of bisphosphonates as a drug delivery mechanism holds immense promise for the future.

Dr.Camel's Conclusion

Like a camel navigating a desert landscape, researchers are diligently seeking new paths to combat bone tumors. Bisphosphonates offer a potential oasis of hope, providing a targeted delivery system that could enhance the efficacy and minimize the side effects of cancer treatments. The journey toward a future where bone tumors are effectively treated continues, and this research provides a roadmap for continued exploration in this promising area.

Date :
  1. Date Completed 2021-06-17
  2. Date Revised 2021-10-02
Further Info :

Pubmed ID

32585321

DOI: Digital Object Identifier

NIHMS1743190

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