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Phase I, first-in-human study of futibatinib, a highly selective, irreversible FGFR1-4 inhibitor in patients with advanced solid tumors.
Author: ArkenauH-T, BahledaR, BenhadjiK A, GoyalL, HeY, MatosI, Meric-BernstamF, TranB, YamamiyaI
Original Abstract of the Article :
Futibatinib is an oral, irreversible, highly selective fibroblast growth factor receptor (FGFR)1-4 inhibitor with potent preclinical activity against tumors harboring FGFR aberrations. This first-in-human, phase I dose-escalation trial (NCT02052778) evaluates the safety and pharmacokinetics/pharmaco...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/32622884
データ提供:米国国立医学図書館(NLM)
Phase I, first-in-human study of futibatinib, a highly selective, irreversible FGFR1-4 inhibitor in patients with advanced solid tumors
This phase I clinical trial explores the safety and effectiveness of futibatinib, a novel drug targeting specific receptors involved in tumor growth. Imagine futibatinib as a precision-guided missile, targeting the specific receptors that fuel the growth of solid tumors. The authors investigated the safety and pharmacokinetics of futibatinib in patients with advanced solid tumors, finding it to be a promising new weapon in the fight against cancer. This research is a beacon of hope in the desert of cancer treatment, offering a potential new path towards effective therapies for patients with advanced solid tumors.
Futibatinib: A Targeted Approach to Cancer Treatment
This phase I trial highlights the potential of futibatinib as a targeted therapy for advanced solid tumors. It's a promising development, offering a new weapon in the battle against cancer and potentially providing a more effective and less toxic treatment option for patients.
Precision Medicine: A New Era in Cancer Treatment
This research showcases the growing field of precision medicine, where treatments are tailored to the specific characteristics of a patient's disease. It's like using a map to navigate a desert, identifying the specific pathways that are fueling tumor growth and targeting those pathways with precision. This approach holds great promise for improving the effectiveness of cancer treatments and improving outcomes for patients.
Dr.Camel's Conclusion
This phase I trial provides encouraging early evidence for the safety and potential effectiveness of futibatinib in patients with advanced solid tumors. It's like discovering a new oasis in the desert of cancer treatment, offering a promising new strategy for combating these aggressive diseases.
Date :
- Date Completed 2021-01-06
- Date Revised 2022-12-13
Further Info :
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