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Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea.

Author: BarrettKim E, DasSoumita, KimYounjoo, QuachAndrew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the mechanisms behind the diarrhea side effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFr TKIs) in patients with cancer. The study found that EGFr TKIs reversed the inhibitory effect of EGF on chloride secretion and reduced transepithelial electrical resistance (TEER) in human colonic epithelial cells, suggesting that these effects contribute to diarrhea. The study also found that co-treatment with carbachol (CCh) delayed the decrease in TEER, highlighting the potential of CCh in mitigating the diarrheal side effects of EGFr TKIs.
Paper Details　
Original Abstract of the Article :
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFr TKIs) are first-line therapies for various cancers, and cause dose-limiting severe diarrhea in many patients. We hypothesized that diarrhea caused by EGFr TKIs might reflect actions on epithelial transport, barrier function, or both, ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354088/

データ提供：米国国立医学図書館（NLM）

Diarrhea's Secret: EGFR TKIs and Gut Barrier Dysfunction

The world of cancer treatment is constantly evolving, with new drugs like epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) offering hope to patients. However, these drugs can have a significant side effect: diarrhea. This study takes us on an expedition into the gut, investigating the mechanisms behind this side effect. The authors found that EGFR TKIs interfere with the normal processes of chloride secretion and barrier function in the gut, which is like disrupting the delicate balance of a desert ecosystem. This disruption can lead to the unwanted flow of water and waste, resulting in diarrhea.

Unraveling the Mechanism: EGFR TKIs and Chloride Secretion

The study showed that EGFR TKIs reverse the effects of epidermal growth factor (EGF) on chloride secretion, a key process in regulating fluid movement in the gut. This is like a disruption in the flow of a desert river, leading to flooding. The authors also observed that EGFR TKIs compromise the gut barrier, which is like weakening the dunes that protect the desert from the encroaching sand. These findings offer insights into the mechanisms underlying diarrhea associated with EGFR TKIs.

Navigating the Side Effects: Strategies for Better Gut Health

Understanding the mechanisms behind EGFR TKI-induced diarrhea can help us develop strategies to mitigate this side effect. This is like finding a way to reinforce the dunes or build canals to manage the flow of water. Further research is needed to develop new therapies or strategies to improve gut health for patients undergoing treatment with EGFR TKIs.

Dr. Camel's Conclusion

The study provides valuable insights into the mechanisms behind EGFR TKI-induced diarrhea, offering a roadmap for developing strategies to mitigate this side effect. As we explore the vast desert of cancer treatment, we must always be vigilant for the potential side effects of new drugs and strive to find ways to minimize their impact on patients' lives.

Date :
  1. Date Completed 2021-06-09
  2. Date Revised 2021-06-09
Further Info :

Pubmed ID

32652816

DOI: Digital Object Identifier

PMC7354088

SNS
PICO Info
in preparation
Languages

English

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