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Sunitinib-induced oxidative imbalance and retinotoxic effects in rats.

Author: AndréHelder, AramburuÓscar, MateAlfonso, Reyes-GoyaClaudia, Santana-GarridoÁlvaro, VázquezCarmen M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the role of NADPH oxidase system and oxidative stress in the eyes of animals treated with sunitinib (Su), a tyrosine kinase inhibitor commonly used for anti-angiogenesis. The study aimed to elucidate the potential mechanisms behind the retinal detachment and photoreceptor damage reported following systemic exposure to Su.
Paper Details　
Original Abstract of the Article :
Sunitinib (Su), a tyrosine kinase inhibitor, is one of the most commonly used anti-angiogenic drugs. Some studies have described retinal detachment and photoreceptor damage following systemic exposure to Su, despite beneficial effects achieved with local treatment of ocular pathologies. The aim of t...See full text at original site
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引用元：
https://doi.org/10.1016/j.lfs.2020.118072

データ提供：米国国立医学図書館（NLM）

Sunitinib: A Double-Edged Sword in Cancer Treatment

Imagine a desert traveler who discovers a powerful elixir that can cure a deadly disease, but also comes with unexpected side effects. This research explores the complexities of sunitinib, a tyrosine kinase inhibitor used to treat various cancers, including kidney cancer.

Sunitinib and Retinal Toxicity

The study focuses on the potential retinal toxicity of sunitinib, a significant concern given its widespread use. The researchers investigated the role of oxidative stress in the development of retinal damage following sunitinib treatment.

Understanding the Mechanisms of Retinal Toxicity

The study suggests that sunitinib can induce oxidative imbalance in the retina, leading to retinal damage. This finding highlights the importance of monitoring for retinal toxicity in patients receiving sunitinib treatment.

Dr. Camel's Conclusion

This research reminds us that even powerful cancer treatments can have unintended consequences. Just as a desert traveler must weigh the risks and benefits of each path, we must carefully consider the potential side effects of cancer drugs while striving to achieve the best outcomes for our patients.

Date :
  1. Date Completed 2020-09-16
  2. Date Revised 2020-09-16
Further Info :

Pubmed ID

32659367

DOI: Digital Object Identifier

10.1016/j.lfs.2020.118072

Related Literature

Article Analysis
・Effects of sunitinib
SNS
PICO Info
in preparation
Languages

English

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