Paper Details

  1. Home
  2. Paper Details

Drug-Drug Interaction Studies of Elagolix with Oral and Transdermal Low-Dose Hormonal Add-Back Therapy.

Author: AliFarah, MostafaNael M, NaderAhmed, ShebleyMohamad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Elagolix, a medication for endometriosis and uterine fibroids pain, might have pharmacokinetic interactions with low-dose hormonal add-back therapy, which is sometimes used to reduce elagolix's side effects. Further research is needed to determine the extent of this interaction.
Paper Details　
Original Abstract of the Article :
Elagolix is an oral, non-peptide, gonadotropin-releasing hormone receptor antagonist. It is approved for the treatment of moderate-to-severe pain associated with endometriosis and is being investigated for the treatment of heavy menstrual bleeding associated with uterine fibroids. Use of low-dose ho...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s40262-020-00921-y

データ提供：米国国立医学図書館（NLM）

Elagolix and Hormonal Add-Back Therapy: A Look at Drug Interactions

Elagolix is a promising new treatment for conditions like endometriosis and uterine fibroids, but like any medication, it can have side effects. This research focused on understanding the interaction between elagolix and hormonal add-back therapy, a common approach to manage the hypoestrogenic effects of elagolix. They conducted a series of studies to investigate potential pharmacokinetic interactions between the two medications. Their findings provide important insights into the safety and effectiveness of using these medications together.

Understanding Drug Interactions

The researchers discovered that elagolix and hormonal add-back therapy could potentially interact with each other, affecting their pharmacokinetic profiles. This information is crucial for doctors to understand the potential consequences of prescribing these medications together. It highlights the importance of carefully considering drug interactions to ensure safe and effective treatment.

Navigating Medication Combinations

For patients receiving elagolix, understanding the potential interactions with hormonal add-back therapy is essential. This research helps doctors make informed decisions about medication combinations, ensuring optimal treatment outcomes and reducing the risk of adverse effects. It underscores the importance of open communication between patients and their doctors to navigate medication combinations safely and effectively.

Dr.Camel's Conclusion

Drug interactions can be a complex puzzle, like trying to navigate a desert with a shifting landscape. This research offers valuable insights into the potential interactions between elagolix and hormonal add-back therapy, helping to guide safe and effective treatment for patients. By carefully considering these interactions, doctors can ensure that patients receive the best possible care, like finding a clear path through a seemingly endless desert.

Date :
  1. Date Completed 2021-10-07
  2. Date Revised 2021-10-07
Further Info :

Pubmed ID

32696440

DOI: Digital Object Identifier

10.1007/s40262-020-00921-y

Related Literature

Article Analysis
・Effects of elagolix
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.