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Symmetric benzidine derivatives as anti-HCV agents: Insight into the nature, stereochemistry of the capping amino acid and the size of the terminal capping carbamates.

Author: AbadiAshraf H, Abdel KarimShereen E, Abdel-HalimMohammad, AhmedNermin S, FrakolakiEfseveia, VassilakiNiki, YoussefYoussef H, ZoidisGrigoris

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A novel symmetric molecule, compound 4, bearing a benzidine prolinamide core, is a potent inhibitor of HCV 1b with high safety profile.
Paper Details　
Original Abstract of the Article :
Novel symmetric molecules, bearing a benzidine prolinamide core, two terminal carbamate caps of variable sizes and nature, including natural and unnatural amino acids were developed. Several terminal N-carbamate substituents of the core structure, ranging from linear methyl, ethyl and butyl groups t...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2020.104089

データ提供：米国国立医学図書館（NLM）

Benzidine Derivatives: A New Oasis in the HCV Desert

Hepatitis C virus (HCV) is a significant global health concern. This study investigated the potential of benzidine derivatives as anti-HCV agents. The researchers synthesized novel symmetric benzidine molecules with different terminal carbamate caps, aiming to develop potent and safe inhibitors of HCV replication.

A Promising Oasis of Inhibition

The study found that one of the synthesized compounds, Compound 4, demonstrated remarkable activity against HCV, with an EC50 of 0.0067 nM. This compound also exhibited a high selectivity index (SI50 > 14788524), suggesting its potential for safe and effective treatment. Compound 4 was effective against multiple genotypes of HCV, making it a promising candidate for broad-spectrum treatment.

Hope for a Healthier HCV Landscape

This research offers hope for the development of new and effective treatments for HCV. The discovery of potent and safe benzidine derivatives could lead to improved therapeutic options for individuals with HCV infection. It's like finding a new oasis in the harsh desert of HCV research, offering potential for healing and recovery.

Dr. Camel's Conclusion

This research explores the potential of benzidine derivatives as anti-HCV agents. The discovery of a potent and safe compound like Compound 4 offers exciting possibilities for the development of new treatments for HCV. It's a reminder that the desert of viral research is constantly evolving, presenting new opportunities for innovation and therapeutic breakthroughs.

Date :
  1. Date Completed 2021-03-02
  2. Date Revised 2021-03-02
Further Info :

Pubmed ID

32717691

DOI: Digital Object Identifier

10.1016/j.bioorg.2020.104089

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English

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