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Assessment of the rapid and sustained antidepressant-like effects of dextromethorphan in mice.

Author: GarrettPatrick I, HillhouseTodd M, HoneycuttSarah C, PetersonAshley M, SaavedraJesus S, WhiteJustin W

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dextromethorphan, an NMDA receptor antagonist, has shown antidepressant-like effects in animal studies. This study investigated the rapid and sustained antidepressant-like effects of dextromethorphan in mice. While dextromethorphan produced acute antidepressant-like effects in the tail suspension test, it failed to show sustained effects. Additionally, dextromethorphan exhibited an anxiogenic-like effect at higher doses. These findings suggest a narrow therapeutic window for dextromethorphan and emphasize the need for further research to understand its mechanisms of action and optimal dosing strategies.
Paper Details　
Original Abstract of the Article :
The glutamatergic system has emerged as a novel pathway for treating major depressive disorder (MDD) with the focus on producing both rapid and sustained antidepressant effects. Dextromethorphan is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist that has produced antidepressant-like...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2020.173003

データ提供：米国国立医学図書館（NLM）

Exploring the Potential of Dextromethorphan for Depression Treatment

The field of [mental health] is always seeking new and effective treatments for [major depressive disorder]. This research delves into the potential of [dextromethorphan] as a rapid and sustained antidepressant, focusing on its effects on the [glutamatergic system]. The researchers employed [novelty-induced hypophagia (NIH) test and tail suspension test (TST)] to assess the antidepressant-like effects of dextromethorphan in mice. They discovered that dextromethorphan exhibited acute antidepressant-like effects in the TST but failed to produce sustained effects 24 hours after administration.

Navigating the Therapeutic Window of Dextromethorphan

The study's findings reveal that dextromethorphan, while demonstrating antidepressant-like effects at certain doses, also exhibited anxiogenic-like behavior at higher doses. This highlights the importance of finding the optimal therapeutic window for dextromethorphan, where its benefits outweigh its potential risks.

Finding the Right Balance for Mental Well-Being

This research underscores the complexity of treating mental health conditions. It's essential to remember that each individual's response to medication can vary. If you're struggling with [depression or anxiety], it's crucial to consult with a qualified mental health professional who can tailor a treatment plan that's right for you.

Dr.Camel's Conclusion

This study sheds light on the fascinating complexity of dextromethorphan's effects. It's like a camel navigating a shifting desert landscape, where the right path depends on the specific conditions. We need to carefully understand the delicate balance of its effects to unlock its true potential as a therapeutic tool. This research serves as a reminder that finding the optimal therapeutic window for medications is crucial for maximizing benefits while minimizing risks, especially in the delicate realm of mental health.

Date :
  1. Date Completed 2021-02-08
  2. Date Revised 2021-02-08
Further Info :

Pubmed ID

32755625

DOI: Digital Object Identifier

10.1016/j.pbb.2020.173003

Related Literature

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・Effects of dextromethorphan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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