Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination.

Author: Bajo-GrañerasRaquel, BaufretonJérôme M, BellocchioLuigi, BlázquezCristina, CannichAstrid, Galve-RoperhIsmael, GuzmánManuel, MarianiYamuna, MarsicanoGiovanni, Pagano ZottolaAntonio C, ReselEva, Rodríguez-NavarroJosé A, Ruiz-CalvoAndrea, VarilhMarjorie

Paper Details 
Original Abstract of the Article :
The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that &#916;<sup>9</sup>-tetrahydrocannabinol, the psychoactive ingredient of cannabis, disrupts autophagy selectively ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417168/

データ提供:米国国立医学図書館(NLM)

Cannabinoid Intoxication: A Maze in the Desert of Motor Control

The effects of cannabinoids, my friends, are a complex and often perplexing subject, like a labyrinthine desert with shifting sands and unexpected turns. This study, published in [Journal Name], explores the link between cannabinoids and motor coordination, focusing on the role of autophagy, a cellular process that clears out cellular debris. Imagine autophagy as a desert wind that sweeps away accumulated sand, maintaining the body's balance and function.

The researchers investigated the effects of Δ9-tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis, on autophagy in the striatum, a brain region crucial for motor control. They found that THC disrupts autophagy in the striatum, potentially leading to impaired motor coordination. They further discovered that boosting autophagy, either through medication or dietary interventions, could reverse THC-induced motor deficits.

The Importance of Autophagy in the Desert of Motor Control

The study's findings highlight the critical role of autophagy in maintaining healthy motor function. Disruptions in autophagy, as seen with THC exposure, can lead to impairments in motor coordination, underscoring the importance of maintaining a balanced and healthy cellular environment.

Navigating the Desert of Cannabinoid Effects

This study offers valuable insights into the complex interplay between cannabinoids, autophagy, and motor control. While THC can disrupt this delicate balance, understanding the mechanisms involved can lead to the development of new therapeutic strategies for managing cannabinoid-induced impairments.

Dr.Camel's Conclusion

This study delves into the intricate maze of cannabinoid effects on motor control, revealing the importance of autophagy in maintaining healthy function. It reminds us that navigating the desert of cannabinoid use requires a deep understanding of the mechanisms involved, paving the way for more targeted and effective therapeutic approaches.

Date :
  1. Date Completed 2021-02-12
  2. Date Revised 2021-02-12
Further Info :

Pubmed ID

32773031

DOI: Digital Object Identifier

PMC7417168

Related Literature

SNS
PICO Info
in preparation
Languages

English

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