Design, Synthesis and Studies on Novel Polymeric Prodrugs of Erlotinib for Colon Drug Delivery.

Author: BhardwajTilak R, KumarSahil, SharmaBandna, SinghRajesh K

Paper Details 
Original Abstract of the Article :
AIMS: In the present study, polymer-drug conjugates were synthesized based on azo-bond cleavage drug delivery approach for targeting erlotinib as an anticancer drug specifically to the colon for the proficient treatment of colon cancer. BACKGROUND: Colon Cancer (CC) is the third commonly detected t...See full text at original site
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引用元:
https://doi.org/10.2174/1871520620666200811124013

データ提供:米国国立医学図書館(NLM)

Polymeric Prodrugs of Erlotinib: A Novel Approach to Colon Cancer Treatment

Colon cancer, a significant health concern worldwide, often requires targeted therapies to minimize side effects. This study explores the potential of polymeric prodrugs of erlotinib, a chemotherapy drug, for specifically targeting colon cancer. The authors propose a novel drug delivery system based on azo-bond cleavage, aiming to achieve site-specific drug release in the colon.

Azo-Bond Cleavage: Targeted Drug Delivery for Colon Cancer

This research presents a promising strategy for delivering erlotinib directly to the colon, minimizing its toxicity to healthy tissues. The authors' approach leverages the unique properties of azo-bond cleavage, which allows for controlled drug release in the presence of specific enzymes found in the colon. This targeted delivery system could potentially improve therapeutic outcomes and reduce adverse effects.

Site-Specific Delivery: A New Frontier in Cancer Treatment

This research highlights the potential of polymeric prodrugs and site-specific drug delivery as a novel approach for treating colon cancer. The study's findings pave the way for exploring new and innovative strategies for delivering chemotherapy drugs directly to the target site, maximizing therapeutic efficacy while minimizing unwanted side effects.

Dr.Camel's Conclusion

Just like a camel navigating a maze of sand dunes, this research explores a clever strategy for directing chemotherapy drugs directly to the colon. The use of polymeric prodrugs and azo-bond cleavage could lead to a more targeted and effective approach to treating colon cancer, offering hope for a smoother journey towards recovery for those affected by this disease.

Date :
  1. Date Completed 2021-10-19
  2. Date Revised 2021-10-19
Further Info :

Pubmed ID

32781967

DOI: Digital Object Identifier

10.2174/1871520620666200811124013

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PICO Info
in preparation
Languages

English

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