Relationship between plasma concentrations and clinical effects of perampanel: A prospective observational study.

Author: , BisulliFrancesca, ContinManuela, FerriLorenzo, LicchettaLaura, MohamedSusan, MuccioliLorenzo, PondrelliFederica, SantucciMargherita, TinuperPaolo

Paper Details 
Original Abstract of the Article :
PURPOSE: The purpose of the study was to investigate the potential correlation between plasma concentration of the newer antiseizure medication (ASM) perampanel (PMP) and both tolerability and seizure control in patients with epilepsy. METHODS: The study design was multicenter, open, and prospectiv...See full text at original site
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引用元:
https://doi.org/10.1016/j.yebeh.2020.107385

データ提供:米国国立医学図書館(NLM)

Perampanel: A Closer Look at Plasma Concentrations and Clinical Effects

This research investigates the relationship between plasma concentrations of perampanel (PMP), a medication used to treat epilepsy, and both tolerability and seizure control. Think of perampanel as a skilled desert navigator, helping to guide the brain through the turbulent waters of seizures, but with some potential side effects. The study examines whether the level of PMP in the blood is associated with the effectiveness and safety of the medication.

The study found no significant correlation between PMP plasma concentrations and either tolerability or seizure control. This is like finding that a desert navigator's compass is not always reliable, sometimes leading to unexpected detours. The study suggests that other factors may be more important in determining the efficacy and safety of PMP.

This study highlights the complexity of drug responses and the need for individualized approaches to medication management. It emphasizes the importance of monitoring patients closely and considering various factors when making decisions about medication adjustments.

Individualized Approaches to Medication Management

This study underscores the importance of individualized approaches to medication management, particularly for medications like perampanel. It emphasizes the need to consider individual patient characteristics and responses when determining the appropriate dosage and treatment strategies.

Understanding Perampanel's Role in Epilepsy Treatment

This study provides valuable insights into the use of perampanel for epilepsy, highlighting the need for careful monitoring and individualized treatment plans. It encourages patients to work closely with their doctors to optimize their treatment and manage any potential side effects.

Dr. Camel's Conclusion

This study is a reminder that the desert of medical knowledge is vast and complex. It encourages us to remain curious and open-minded, always seeking new knowledge and understanding to improve patient care.

Date :
  1. Date Completed 2021-04-14
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

32858369

DOI: Digital Object Identifier

10.1016/j.yebeh.2020.107385

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English

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