Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia.

Author: , BartuliAndrea, BergeronJean, BridgesIan, DescampsOlivier S, GaudetDaniel, Greber-PlatzerSusanne, HamerAndrew, HovinghG Kees, KasteleinJohn J P, KurtzChristopher E, LuirinkIlse, MachFrançois, RuzzaAndrea, SantosRaul D, SantraSaikat, StefanuttiClaudia, SzamosiTamás, WiegmanAlbert

Paper Details 
Original Abstract of the Article :
BACKGROUND: Evolocumab, a fully human monoclonal antibody directed against proprotein convertase subtilisin-kexin type 9, is widely used in adult patients to lower low-density lipoprotein (LDL) cholesterol levels. Its effects in pediatric patients with heterozygous familial hypercholesterolemia are ...See full text at original site
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引用元:
https://doi.org/10.1056/NEJMoa2019910

データ提供:米国国立医学図書館(NLM)

Evolocumab: A New Hope for Pediatric Familial Hypercholesterolemia

Familial hypercholesterolemia, a genetic condition that elevates cholesterol levels, is a challenging desert to navigate, particularly for children. This research examines the efficacy and safety of evolocumab, a monoclonal antibody used to lower LDL cholesterol levels, in pediatric patients with heterozygous familial hypercholesterolemia. The authors conducted a randomized, double-blind, placebo-controlled trial to evaluate the drug's effects in this population.

Evolocumab's Promise for Pediatric Patients

The study found that evolocumab significantly reduced LDL cholesterol levels in pediatric patients with familial hypercholesterolemia. This finding suggests that evolocumab may be a valuable therapeutic option for managing cholesterol levels in children with this genetic condition. The authors also found that evolocumab was well-tolerated in this population, providing further evidence of its potential safety and efficacy.

Navigating Cholesterol Levels in Children

This research provides promising evidence for the efficacy and safety of evolocumab in pediatric patients with familial hypercholesterolemia. It offers new hope for managing cholesterol levels in this vulnerable population. As we navigate the desert of pediatric lipid disorders, we must continue to explore new therapeutic approaches to ensure the healthy development of our children.

Dr.Camel's Conclusion

This research demonstrates the potential of evolocumab as a safe and effective treatment option for pediatric patients with familial hypercholesterolemia. The drug’s ability to reduce LDL cholesterol levels offers new hope for managing this challenging condition in children.

Date :
  1. Date Completed 2020-10-16
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

32865373

DOI: Digital Object Identifier

10.1056/NEJMoa2019910

Related Literature

SNS
PICO Info
in preparation
Languages

English

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