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Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.

Author: BjörndahlLars, Darreh-ShoriTaher, FlanaganJohn, KumarAmit, KumarRajnish, LångströmBengt

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study investigated the impact of esomeprazole, a commonly used proton pump inhibitor (PPI), on human sperm function. Results showed that esomeprazole acts as a potent inhibitor of choline acetyltransferase (ChAT), an enzyme crucial for sperm motility. This inhibition significantly reduced sperm motility by 36% and 21% at 10 and 100 nM, respectively. These findings suggest a potential link between PPI use and male infertility.
Paper Details　
Original Abstract of the Article :
Recent studies have linked prolonged use of the most commonly prescribed proton pump inhibitors (PPIs) with declined human sperm function and infertility. Here, we report for the first time the most plausible underlying mechanism for this unwarranted secondary mode of action. We followed up on a rec...See full text at original site
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引用元：
https://doi.org/10.1016/j.bcp.2020.114212

データ提供：米国国立医学図書館（NLM）

Esomeprazole: Impact on Sperm Motility and Potential for Infertility

Proton pump inhibitors (PPIs) are widely used to treat gastrointestinal disorders. This study investigates the potential impact of esomeprazole, a common PPI, on sperm motility. Like a curious camel exploring a hidden oasis, this research uncovers a potential unintended consequence of a commonly prescribed medication.

Esomeprazole and Sperm Motility

The study found that esomeprazole significantly reduced sperm motility in vitro. This suggests that long-term use of PPIs may have an adverse effect on male fertility. Further research is needed to confirm this finding in vivo and to investigate the potential implications for male reproductive health.

Potential Implications for Male Fertility

This study raises concerns about the potential impact of PPIs on male fertility. It underscores the importance of considering the broader effects of medications, even those that are widely used, on overall health and well-being.

Dr. Camel's Conclusion

This study serves as a reminder that even seemingly innocuous medications can have unintended consequences. It highlights the need for ongoing research to assess the potential impact of medications on reproductive health and to develop safer alternatives.

Date :
  1. Date Completed 2021-01-21
  2. Date Revised 2021-01-21
Further Info :

Pubmed ID

32866455

DOI: Digital Object Identifier

10.1016/j.bcp.2020.114212

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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