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Non-Hematologic Toxicity of Bortezomib in Multiple Myeloma: The Neuromuscular and Cardiovascular Adverse Effects.

Author: GuglielmiValeria, MalatestaManuela, NowisDominika, PancheriElia, TomelleriGiuliano, ToninPaola, VattemiGaetano, WilczynskiGrzegorz M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The study reviews the neuromuscular and cardiovascular side effects of bortezomib, a proteasome inhibitor used in the treatment of multiple myeloma (MM), focusing on the molecular mechanisms underlying its toxicity.
Paper Details　
Original Abstract of the Article :
The overall approach to the treatment of multiple myeloma (MM) has undergone several changes during the past decade. and proteasome inhibitors (PIs) including bortezomib, carfilzomib, and ixazomib have considerably improved the outcomes in affected patients. The first-in-class selective PI bortezomi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563977/

データ提供：米国国立医学図書館（NLM）

Bortezomib: A Double-Edged Sword in Multiple Myeloma Treatment

This review examines the non-hematologic toxicities of bortezomib, a proteasome inhibitor widely used in the treatment of multiple myeloma (MM). The authors discuss the potential neuromuscular and cardiovascular side effects of bortezomib, highlighting the need for careful monitoring and management of these toxicities. This review aims to raise awareness of the potential side effects of bortezomib and provide guidance for clinicians managing MM patients.

Bortezomib: Balancing Efficacy with Safety

This review emphasizes the importance of balancing the efficacy of bortezomib with the potential for side effects. The authors highlight the need for close monitoring and management of neuromuscular and cardiovascular toxicities to ensure optimal patient outcomes. This research provides valuable insights for clinicians treating MM patients with bortezomib.

Navigating the Desert of Side Effects

Bortezomib, like a powerful desert wind, can sometimes cause unwelcome side effects. This review provides a map for navigating these side effects and ensuring the safe and effective use of this important drug in the treatment of multiple myeloma.

Dr.Camel's Conclusion

Bortezomib, like a powerful camel, can carry us through the desert of multiple myeloma, but we must be mindful of the potential side effects and navigate carefully to ensure a smooth journey.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-28
Further Info :

Pubmed ID

32906684

DOI: Digital Object Identifier

PMC7563977

SNS
PICO Info
in preparation
Languages

English

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