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Use of SGLT2 inhibitors in cardiovascular diseases: why, when and how?
Author: HullinRoger, LuHenri, MeyerPhilippe
Original Abstract of the Article :
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of drugs that reduce blood glucose levels by increasing urinary glucose excretion. On top of the glucose-lowering effect, they offer cardiovascular and renal benefits, the mechanisms of which are probably pleiotropic and include blood...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/32920793
データ提供:米国国立医学図書館(NLM)
SGLT2 Inhibitors: Oasis in the Desert of Diabetes
The desert of type 2 diabetes is vast and unforgiving, but researchers are constantly seeking new oases of hope. This review delves into the emerging class of [SGLT2 inhibitors], a new kind of desert flower blooming with potential to combat the disease. These inhibitors, by [increasing urinary glucose excretion], act like a desert well, drawing out excess glucose from the body. The review discusses how these inhibitors offer [cardiovascular and renal benefits] in addition to their glucose-lowering effect, making them a valuable tool for managing type 2 diabetes. This is like finding a hidden oasis with not only a well of water but also a lush garden and a welcoming haven from the harsh desert conditions.
A Multifaceted Oasis
The review highlights the [pleiotropic mechanisms] of SGLT2 inhibitors, which contribute to their multifaceted benefits. These inhibitors not only lower blood glucose but also [reduce blood pressure, decrease volume, promote weight loss, and enhance metabolic function]. This is like finding an oasis with a well, a spring, a shady grove, and a fertile garden - a true treasure in the desert. These findings further demonstrate the potential of SGLT2 inhibitors to become a cornerstone of diabetes treatment, offering a comprehensive solution to a complex challenge.
Hydrating the Desert
The study underscores the importance of [understanding the potential side effects of SGLT2 inhibitors]. While these inhibitors offer a valuable oasis in the desert of diabetes, we must be mindful of the [risk of euglycaemic diabetic ketoacidosis, genital mycotic infections, lower limb amputations, and fractures], which may arise from their use. Like a desert traveler, we must be aware of the potential hazards and take necessary precautions to ensure our well-being. However, despite these potential risks, the study suggests that SGLT2 inhibitors offer a valuable oasis in the desert of diabetes, offering a lifeline for patients struggling with the disease.
Dr. Camel's Conclusion
The discovery of SGLT2 inhibitors offers a beacon of hope in the vast desert of diabetes. Their multifaceted benefits and potential to improve cardiovascular and renal health are like finding a hidden oasis with a well of water, a spring, a shady grove, and a fertile garden. However, as with any desert journey, we must remain vigilant about potential risks and ensure that patients receive comprehensive care to maximize the benefits and minimize the hazards of these novel drugs.
Date :
- Date Completed 2021-08-18
- Date Revised 2021-08-18
Further Info :
Related Literature
English
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